发明授权
US5770568A Variants of bovine pancreatic trypsin inhibitor produced by recombinant
DNA technology, process expression vector and recombinant host therefor
and pharmaceutical use thereof
失效
通过重组DNA技术产生的牛胰胰蛋白酶抑制剂的变体，过程表达载体及其重组宿主及其药物用途
- 专利标题： Variants of bovine pancreatic trypsin inhibitor produced by recombinant DNA technology, process expression vector and recombinant host therefor and pharmaceutical use thereof
- 专利标题（中）： 通过重组DNA技术产生的牛胰胰蛋白酶抑制剂的变体，过程表达载体及其重组宿主及其药物用途
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申请号： US369987申请日： 1995-01-09
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公开(公告)号： US5770568A公开(公告)日： 1998-06-23
- 发明人: Ernst-August Auerswald , Wolfgang Bruns , Dietrich Horlein , Gerd Reinhardt , Eugen Schnabel , Werner Schroder
- 申请人： Ernst-August Auerswald , Wolfgang Bruns , Dietrich Horlein , Gerd Reinhardt , Eugen Schnabel , Werner Schroder
- 申请人地址： DEX Leverkusen
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： DEX Leverkusen
- 优先权： GBX8718777 19870807
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; A61K38/00 ; A61K38/55 ; A61P9/00 ; A61P29/00 ; C07K14/00 ; C07K14/81 ; C12N1/21 ; C12N15/09 ; C12P21/02 ; A61K38/57
摘要：
Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.
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