Invention Grant
- Patent Title: Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
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Application No.: US473647Application Date: 1995-06-06
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Publication No.: US5770600APublication Date: 1998-06-23
- Inventor: Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt
- Applicant: Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt
- Applicant Address: CA San Diego
- Assignee: Corvas International, Inc.
- Current Assignee: Corvas International, Inc.
- Current Assignee Address: CA San Diego
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P7/02 ; C07K5/06 ; C07K5/062 ; C07K5/072 ; C07K5/078 ; A61K31/535 ; A61K31/445 ; C07D401/12 ; C07D413/12
Abstract:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
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