发明授权
- 专利标题： Optically active .alpha.-substituted carboxylic acid derivatives and method for producing the same
- 专利标题（中）： 光学活性α-取代羧酸衍生物及其制备方法
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申请号： US750761申请日： 1996-12-12
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公开(公告)号： US5773240A公开(公告)日： 1998-06-30
- 发明人: Eiji Ozaki , Toshitaka Uragaki , Keiichi Sakashita , Tetsuya Ikemoto , Yoshimasa Kobayashi , Akihiro Sakimae
- 申请人： Eiji Ozaki , Toshitaka Uragaki , Keiichi Sakashita , Tetsuya Ikemoto , Yoshimasa Kobayashi , Akihiro Sakimae
- 申请人地址： JPX Tokyo
- 专利权人： Mitsubishi Rayon Co., Ltd.
- 当前专利权人： Mitsubishi Rayon Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX6-130590 19940613; JPX6-134700 19940616; JPX7-66416 19950324
- 主分类号： C07C53/128
- IPC分类号： C07C53/128 ; C07C55/02 ; C07C55/32 ; C07C57/13 ; C07C59/01 ; C07C59/115 ; C07C69/34 ; C07C69/593 ; C07C69/675 ; C12P41/00 ; C12P1/00 ; C12P7/44
摘要：
The present invention relates to an optically active .alpha.-substituted carboxylic acid derivative represented by the general formula (I): ##STR1## (wherein R.sub.1 is a hydroxyl group, ##STR2## R.sub.2 is a methyl group or a chlorine atom; R.sub.3 is a hydrogen atom or an alkyl group with 1-6 carbon atoms; n is an integer of 1 or 2; and * represents an asymmetric carbon atom, provided that R.sub.2 is a chlorine atom when R.sub.1 is a hydroxyl group); and a method for producing the optically active .alpha.-substituted carboxylic acid derivative represented by the general formula (I) and antipodes thereof using a culture, cells or a material obtainable from cells of a microorganism having an ability to asymmetrically hydrolyze ester bonds. The optically active .alpha.-substituted carboxylic acid derivatives and antipodes thereof provided by the invention are useful as raw materials for various liquid crystals and as synthetic intermediates for various optically active medicines or agricultural chemicals.