发明授权
US5789182A System for assaying binding to a heparin-binding growth factor receptor
失效
用于测定与肝素结合生长因子受体结合的系统
- 专利标题： System for assaying binding to a heparin-binding growth factor receptor
- 专利标题（中）： 用于测定与肝素结合生长因子受体结合的系统
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申请号： US166717申请日： 1993-12-14
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公开(公告)号： US5789182A公开(公告)日： 1998-08-04
- 发明人: Avner Yayon , David M. Ornitz , Michael Klagsbrun , Philip Leder , John G. Flanagan
- 申请人： Avner Yayon , David M. Ornitz , Michael Klagsbrun , Philip Leder , John G. Flanagan
- 申请人地址： MA Boston MA Boston
- 专利权人： The Children's Medical Center Corporation,President and Fellows of Harvard College
- 当前专利权人： The Children's Medical Center Corporation,President and Fellows of Harvard College
- 当前专利权人地址： MA Boston MA Boston
- 主分类号： C07K14/50
- IPC分类号： C07K14/50 ; C07K14/71 ; C12N9/16 ; G01N33/50 ; G01N33/74 ; C12Q1/00 ; C12N15/09
摘要：
A homogeneous population of cells having on average (1) a number of cell surface low-affinity heparin-binding growth factor (HBGF) sites per cell less than 20% of the number of such binding sites found on wild-type CHO-K1 cells (ATCC Accession No. CCL61), and at least three times the number of cell surface high-affinity HBGF receptors per cell found on such CHO-K1 cells; and an assay system utilizing such cells.
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