发明授权
US5789573A Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
失效
ICAM-1，E-选择蛋白和CMV IE1 / IE2的反义抑制
- 专利标题： Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
- 专利标题（中）： ICAM-1，E-选择蛋白和CMV IE1 / IE2的反义抑制
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申请号： US653653申请日： 1996-05-24
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公开(公告)号： US5789573A公开(公告)日： 1998-08-04
- 发明人: Brenda Baker , C. Frank Bennett , Kevin P. Anderson
- 申请人： Brenda Baker , C. Frank Bennett , Kevin P. Anderson
- 申请人地址： CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： CA Carlsbad
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/00 ; A61K31/70 ; A61K31/7088 ; A61K31/712 ; A61K38/00 ; A61K48/00 ; A61P29/00 ; A61P31/00 ; A61P31/22 ; A61P37/00 ; A61P37/02 ; C07H21/00 ; C07K14/045 ; C07K14/705 ; C12N9/12 ; C12N15/113 ; C12Q1/70 ; C07H21/02 ; C07H21/04 ; C12Q1/68
摘要：
Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably said oligomers inhibit protein translation directly via interference with ribosome assembly.
公开/授权文献
- US5183571A Multilayer membrane and process of manufacturing the same 公开/授权日：1993-02-02
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