An endoscopic bioptome includes a flexible coil having a lumen with an axially displaceable wire extending therethrough. The proximal ends of the coil and wire are coupled to a manual actuator for axially displacing one of the coil and wire relative to the other. The distal end of the coil is coupled to either a jaw assembly or a cylinder. The jaw assembly includes a pair of jaws each having a distal jaw cup having a proximal neck and a relatively narrow bent resilient arm. The distal end of the wire is coupled to the other of the cylinder or the jaw assembly. The cylinder is slidable over the jaw assembly. Axial movement of either the wire relative to the coil or vice versa moves the cylinder over the arms of the jaws and over the necks of the jaw cups, thereby forcing the jaw cups together in a biting action. In one embodiment, the axially displaceable wire is provided with a coaxial stopping band or sleeve which stops its movement as soon as the jaws close. In another embodiment, the cylinder is provided with an annular stopping crimp which limits relative displacement of the cylinder and the jaw assembly. In a third embodiment, the cylinder is provided with a radially inward flange and the coil is provided with a reduced diameter portion. In a fourth embodiment, the jaw cups are provided with outer surface steps. In all of the embodiments, the limitation of displacement has the effect of limiting the cutting force applied to the jaws.