发明授权
- 专利标题： Inhibitors of IMPDH enzyme
- 专利标题（中）： IMPDH酶抑制剂
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申请号： US636361申请日： 1996-04-23
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公开(公告)号： US5807876A公开(公告)日： 1998-09-15
- 发明人: David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
- 申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
- 申请人地址： MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K31/17
- IPC分类号： A61K31/17 ; A61K31/18 ; A61K31/404 ; A61K31/42 ; A61K31/421 ; A61K31/422 ; A61P9/14 ; A61P29/00 ; A61P31/12 ; A61P35/00 ; A61P37/06 ; A61P43/00 ; C07C275/42 ; C07D263/18 ; C07D263/32 ; C07D277/18 ; C07D413/12 ; C07D263/34 ; C07D413/00
摘要：
The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
公开/授权文献
- US4095087A Miniature system for central heating and water heating 公开/授权日：1978-06-13
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