发明授权
- 专利标题: Azole derivative and pharmaceutical composition thereof
- 专利标题(中): 唑衍生物及其药物组合物
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申请号: US619629申请日: 1996-03-26
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公开(公告)号: US5807880A公开(公告)日: 1998-09-15
- 发明人: Minoru Okada , Toru Yoden , Eiji Kawaminami , Yoshiaki Shimada , Tsukasa Ishihara , Masafumi Kudou
- 申请人: Minoru Okada , Toru Yoden , Eiji Kawaminami , Yoshiaki Shimada , Tsukasa Ishihara , Masafumi Kudou
- 申请人地址: JPX Tokyo
- 专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-244944 19930930
- 主分类号: C07D233/56
- IPC分类号: C07D233/56 ; C07D249/08 ; C07D521/00 ; A61K31/415 ; C07D403/06
摘要:
An azole derivative represented by the following general formula (I) ##STR1## (symbols in the formula have the following meanings; R.sup.1 and R.sup.2 : the same or different from each other and each represents a hydrogen atom, a lower alkyl group or a phenyl group which may be substituted with a halogen atom, A, B and D: the same or different from one another and each represents a group represented by the formula ##STR2## or a nitrogen atom, X and Y: the same or different from each other and each represents a single bond, a methylene group, an oxygen atom, a group represented by a formula S(O).sub.n, or a group represented by the formula ##STR3## R.sup.3 and R.sup.4 : the same or different from each other and each represents a hydrogen atom or a lower alkyl group, and n: 0, 1 or 2), a salt thereof, a hydrate thereof or a solvate thereof. This compound has a function to inhibit steroid 17-20 lyase and is useful as preventive and treating agents for prostatic cancer, prostatic hypertrophy, virilism, breast cancer, mastopathy, histeromyoma, and endometriosis.