发明授权
- 专利标题： Method of producing human pluripotent hematopoietic colony stimulating factor
- 专利标题（中）： 产生人多能造血集落刺激因子的方法
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申请号： US816159申请日： 1997-03-12
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公开(公告)号： US5808008A公开(公告)日： 1998-09-15
- 发明人: Karl Welte , Erich Platzer , Janice L. Gabrilove , Roland Mertelsmann , Malcolm A. S. Moore
- 申请人： Karl Welte , Erich Platzer , Janice L. Gabrilove , Roland Mertelsmann , Malcolm A. S. Moore
- 申请人地址： NY New York
- 专利权人： Sloan-Kettering Institute of Cancer Research
- 当前专利权人： Sloan-Kettering Institute of Cancer Research
- 当前专利权人地址： NY New York
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/18 ; A61K38/19 ; C07H21/04 ; C07K1/14 ; C07K1/18 ; C07K1/22 ; C07K1/30 ; C07K14/435 ; C07K14/475 ; C07K14/52 ; C07K14/53 ; C07K14/535 ; C07K14/575 ; C12N5/08 ; C12P21/02
摘要：
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.
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