发明授权
- 专利标题： Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
- 专利标题（中）： 含硫膦酸酯化合物，药物组合物和治疗异常钙和磷酸盐代谢的方法
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申请号： US301514申请日： 1994-09-07
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公开(公告)号： US5824661A公开(公告)日： 1998-10-20
- 发明人: Marion David Francis , Susan Mary Kaas , Frank Hallock Ebetino
- 申请人： Marion David Francis , Susan Mary Kaas , Frank Hallock Ebetino
- 申请人地址： OH Cincinnati
- 专利权人： The Procter & Gamble Company
- 当前专利权人： The Procter & Gamble Company
- 当前专利权人地址： OH Cincinnati
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A61K31/662 ; A61K31/663 ; A61K31/665 ; A61K31/67 ; A61K31/675 ; A61P3/00 ; A61P3/14 ; A61P19/08 ; A61P19/10 ; A61P29/00 ; A61P43/00 ; C07F20060101 ; C07F9/30 ; C07F9/38 ; C07F9/40 ; C07F9/547 ; C07F9/553 ; C07F9/572 ; C07F9/576 ; C07F9/58 ; C07F9/59 ; C07F9/6506 ; C07F9/6512 ; C07F9/655 ; C07F9/6553 ; C07F9/6561
摘要：
Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S(b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing one or more heteroatoms selected from O, S, or N; (c) Q is covalent bond; O; or S; (d) R is COOH, SO.sub.3 H, PO.sub.3 H.sub.2, or P(O)(OH)R.sup.4, wherein R.sup.4 is C.sub.1 -C.sub.8 alkyl; (e) R.sup.1, R.sup.2 and R.sup.5 are as defined in the claims. are useful in the treatment of calcium and phosphate elated disorders, such as arthritis and the like.
公开/授权文献
- US4924090A Double focusing mass spectrometer and MS/MS arrangement 公开/授权日：1990-05-08
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