- 专利标题: Comparative fluorescence hybridization to nucleic acid arrays
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申请号: US353018申请日: 1994-12-09
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公开(公告)号: US5830645A公开(公告)日: 1998-11-03
- 发明人: Daniel Pinkel , Donna Albertson , Joe W. Gray
- 申请人: Daniel Pinkel , Donna Albertson , Joe W. Gray
- 申请人地址: CA Oakland GB2 Cambridge
- 专利权人: The Regents of the University of California,The Medical Research Council
- 当前专利权人: The Regents of the University of California,The Medical Research Council
- 当前专利权人地址: CA Oakland GB2 Cambridge
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; C07H19/04 ; C07H21/04 ; C12N15/09 ; C12P19/34 ; C12Q1/68 ; G01N37/00 ; G06F19/20 ; G06K9/40 ; G06K9/58 ; G06K9/60 ; G06T1/00 ; G06T1/40
摘要:
The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.