发明授权
US5834420A Fibrinogen concentrate obtained from blood plasma, process and plant for
its preparation
失效
从血浆，过程和植物中获得的纤维蛋白原浓缩物用于其制备
- 专利标题： Fibrinogen concentrate obtained from blood plasma, process and plant for its preparation
- 专利标题（中）： 从血浆，过程和植物中获得的纤维蛋白原浓缩物用于其制备
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申请号： US765838申请日： 1997-07-07
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公开(公告)号： US5834420A公开(公告)日： 1998-11-10
- 发明人: Ruth Laub , Luc De Wael
- 申请人： Ruth Laub , Luc De Wael
- 申请人地址： BEX Brussels
- 专利权人： Croix-Rouge de Belgique
- 当前专利权人： Croix-Rouge de Belgique
- 当前专利权人地址： BEX Brussels
- 优先权： EPX94870121 19950823
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K35/14 ; A61K38/36 ; A61L2/00 ; A61L2/18 ; A61L26/00 ; A61P7/04 ; A61P43/00 ; C07K1/18 ; C07K1/34 ; C07K1/36 ; C07K14/75 ; C07K1/00 ; C07K14/00 ; C07K17/00
摘要：
A fibrinogen concentrate has a purity of 98% or higher and is free of viral contaminants and proteases. The fibrinogen concentrate is obtained by subjecting a solubilized plasma fraction containing fibrinogen to a viral inactivation chemical treatment using a solvent/detergent, subjecting the resulting viral-inactivated fraction to precipitation in a solution containing an amino acid at an acidic pH to obtain a supernatant, filtering the supernatant to obtain a purified fibrinogen concentrate, and recovering the purified fibrinogen concentrate.
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