- 专利标题： Dihydropyrones with improved antiviral activity
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申请号： US883743申请日： 1997-06-27
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公开(公告)号： US5834506A公开(公告)日： 1998-11-10
- 发明人: Frederick Earl Boyer, Jr. , John Michael Domagala , Edmund Lee Ellsworth , Christopher Andrew Gajda , Susan Elizabeth Hagen , Harriet Wall Hamilton , Elizabeth Ann Lunney , Larry James Markoski , Josyula Venkata Nagendra Vara Prasad , Bradley Dean Tait
- 申请人： Frederick Earl Boyer, Jr. , John Michael Domagala , Edmund Lee Ellsworth , Christopher Andrew Gajda , Susan Elizabeth Hagen , Harriet Wall Hamilton , Elizabeth Ann Lunney , Larry James Markoski , Josyula Venkata Nagendra Vara Prasad , Bradley Dean Tait
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： C07D295/22
- IPC分类号： C07D295/22 ; A61K31/366 ; A61K31/381 ; A61K31/4178 ; A61K31/4433 ; A61K31/453 ; A61K31/496 ; A61K31/5355 ; A61P31/18 ; C07C39/26 ; C07C43/225 ; C07C49/255 ; C07C59/48 ; C07C59/52 ; C07C59/68 ; C07C69/734 ; C07C69/738 ; C07C233/33 ; C07C381/04 ; C07D233/84 ; C07D233/86 ; C07D241/04 ; C07D295/205 ; C07D309/32 ; C07D405/04 ; C07D405/12 ; C07D409/12 ; C07F7/08 ; C07F7/18 ; A61K31/35 ; A61K31/415
摘要：
This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish cytotoxicity further enhancing the desirable properties of these agents as antivirals.
公开/授权文献
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