发明授权
- 专利标题： Chimeric hepatitis A vaccine
- 专利标题（中）： 嵌合甲型肝炎疫苗
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申请号： US473304申请日： 1995-06-07
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公开(公告)号： US5837260A公开(公告)日： 1998-11-17
- 发明人: Jeffrey I. Cohen , Robert H. Purcell , Stephen M. Feinstone , John R. Ticehurst
- 申请人： Jeffrey I. Cohen , Robert H. Purcell , Stephen M. Feinstone , John R. Ticehurst
- 申请人地址： DC Washington
- 专利权人： The United of America as represented by the Department of Health and Human Services
- 当前专利权人： The United of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/29 ; C07K14/10 ; C12N7/00 ; C12N7/02 ; C12N7/08 ; C12N15/51 ; A61K39/12 ; C12N7/04
摘要：
A full-length cDNA copy of an attenuated, cell culture-adapted hepatitis-A virus genome has been constructed. The HAV cDNA when inserted, without the oligo (dG) oligo (dC) tails, into an RNA transcription vector yielded a plasmid designated pHAV/7. Transfection of monkey kidney cells with pHAV/7 DNA yielded HAV. Transfection with RNA transcripts produced in vitro from pHAV/7 yielded about 10-fold more HAV than transfection with pHAV/7 DNA. HAV thus produced are useful as a vaccine.
公开/授权文献
- USRE31806E Monolithic multi-emitting laser device 公开/授权日：1985-01-15
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