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1.发明申请MONOCLONAL ANTIBODIES AGAINST DENGUE AND OTHER VIRUSES WITH DELETION IN FC REGION 审中-公开针对东盟地区的登革热和其他病毒的单克隆抗体公开(公告)号：US20130344058A1
公开(公告)日：2013-12-26
申请号：US13722275
申请日：2012-12-20
IPC分类号： C07K16/10
CPC分类号： C07K16/1081 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/76 , Y02A50/386
摘要： The present invention relates to a variant of a parent polypeptide comprising an Fc region, which variant binds an Fc gamma receptor (FcγR) with lower affinity than the parent polypeptide and comprises a deletion of at least one amino acid in about position 100 to about position 150 in the Fc region and related nucleic acids, vectors, host cells and methods of producing the variant and methods for preventing or treating a disorder in a mammal.
摘要翻译： 本发明涉及包含Fc区的亲本多肽的变体，该变体以比亲本多肽更低的亲和力结合Fcγ受体（FcγR），并且包含约100位至约位置的至少一个氨基酸的缺失 Fc区和相关核酸，载体，宿主细胞和产生变体的方法以及用于预防或治疗哺乳动物疾病的方法。
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公开(公告)号：US20130302790A1
公开(公告)日：2013-11-14
申请号：US13978839
申请日：2012-01-10
申请人： Suzanne U. Emerson , Priyanka Shukla , Hanh T. Nguyen , Robert H. Purcell , Harry R. Dalton , Richard Bendall
发明人： Suzanne U. Emerson , Priyanka Shukla , Hanh T. Nguyen , Robert H. Purcell , Harry R. Dalton , Richard Bendall
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/47 , C12N15/86 , C12N2770/28121 , C12N2770/28122 , C12N2770/28134 , C12N2770/28143 , C12N2770/28151 , C12N2770/28152 , C12Q1/707
摘要： The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
摘要翻译： 本发明涉及从长期感染的患者中发现HEV毒株。 病毒在许多细胞培养物中异常生长。 因此，本发明提供了基于病毒的细胞培养物，载体和疫苗组合物。 本发明部分地涉及鉴定新型HEV基因型3病毒株。 使用从慢性感染患者中分离的HEV菌株Kernow-C1（基因型3），用于鉴定允许感染的人，猪和鹿细胞系。 将Kernow-C 1菌株适应于人肝癌细胞中生长，其选择含有人核糖体蛋白基因的174个核糖核苷酸（58个氨基酸）和另外的突变的稀有病毒重组体。
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3.发明申请HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE JAPANESE ENCEPHALITIS VIRUS (JEV) AND THEIR USE 有权特异性和/或中和日本食物病毒（JEV）及其使用的人类单克隆抗体公开(公告)号：US20110033462A1
公开(公告)日：2011-02-10
申请号：US12937227
申请日：2009-04-10
CPC分类号： C07K16/1081 , A61K47/6841 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/569 , G01N33/56983 , G01N2333/185 , Y02A50/39
摘要： Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM or less. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. Methods of treating, preventing, and/or ameliorating JEV infection in a subject with JEV also are disclosed. Additionally, the antibodies can be used to detect JEV in a sample, and methods of diagnosing JEV infection, or confirming a diagnosis of JEV infection in a subject, are disclosed herein that utilize these antibodies.
摘要翻译： 本文公开了以约1.0nM或更低的结合亲和力特异性结合日本脑炎病毒（JEV）的分离的人源化单克隆抗体。 还公开了编码这些抗体的核酸，包括这些核酸分子的表达载体和表达核酸分子的分离的宿主细胞。 用JEV治疗，预防和/或改善受试者的JEV感染的方法也被公开。 此外，抗体可以用于检测样品中的JEV，并且本文公开了利用这些抗体的方法来诊断受试者中的JEV感染或确认JEV感染的诊断。
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4.发明申请CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF 审中-公开感染性HEPATITIS C病毒株HC-TN的克隆基因及其用途公开(公告)号：US20100291130A1
公开(公告)日：2010-11-18
申请号：US12637696
申请日：2009-12-14
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , G01N2500/10
摘要： Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
摘要翻译： 本文描述的实施方案包括编码菌株HC-TN的丙型肝炎病毒，基因型1a，蛋白质和多肽及其片段的核酸序列。 还考虑使用这些组合物和HCV的诊断以及开发用于鉴定HCV的抗病毒剂的筛选测定法。
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5.发明申请CLONED GENOME OF INFECTIOUS HEPATITIS C VIRUS STRAIN HC-TN AND USES THEREOF 失效感染性HEPATITIS C病毒株HC-TN的克隆基因及其用途公开(公告)号：US20090252755A1
公开(公告)日：2009-10-08
申请号：US12061504
申请日：2008-04-02
申请人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
发明人： Jens Bukh , Robert H. Purcell , Suzanne U. Emerson , Akito Sakai
IPC分类号： A61K39/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , A61P37/00 , C12N15/87 , C12Q1/70 , C12Q1/34 , C12Q1/37
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , G01N2500/10
摘要： Embodiments described herein include nucleic acid sequences, which encode hepatitis C virus of strain HC-TN, genotype 1a, proteins and polypeptides and fragments thereof. Use of these compositions, and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV are also contemplated.
摘要翻译： 本文描述的实施方案包括编码菌株HC-TN的丙型肝炎病毒，基因型1a，蛋白质和多肽及其片段的核酸序列。 还考虑使用这些组合物和HCV的诊断以及开发用于鉴定HCV的抗病毒剂的筛选测定法。
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6.发明授权Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C 失效肝细胞C病毒E2糖蛋白特异性单克隆抗体及其在丙型肝炎诊断，治疗和预防中的应用公开(公告)号：US06924362B2
公开(公告)日：2005-08-02
申请号：US10432006
申请日：2001-11-30
IPC分类号： A61K39/395 , A61P1/16 , A61P31/12 , C07K16/08 , C07K16/10 , C07K16/42 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/576 , G01N33/577 , G01N33/68 , C07K16/00 , A61K39/42 , C12Q1/70 , G01N33/53
CPC分类号： G01N33/6878 , A61K2039/505 , C07K16/109 , C07K16/4216 , C07K2317/21 , C07K2317/55 , C07K2317/565 , G01N33/5767 , G01N2333/18
摘要： The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.
摘要翻译： 本发明描述了从噬菌体展示文库分离的五种人HC E1特异性单克隆抗体的鉴定和鉴定及其在哺乳动物，优选人类中诊断，治疗和预防HCV的用途。
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7.发明授权Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines 有权巴基斯坦戊型肝炎病毒的重组蛋白及其在诊断方法和疫苗中的应用公开(公告)号：US06458562B1
公开(公告)日：2002-10-01
申请号：US09402776
申请日：2000-02-22
IPC分类号： C12N1551
CPC分类号： C07K14/005 , C12N2770/28122 , Y10S977/804
摘要： The invention relates to the expression of open reading frame 2 (ORF-2) proteins of a strain of hepatitis E virus from Pakistan (SAR-55) in a eukaryotic expression system. The expressed proteins can serve as an antigen in diagnostic immunoassays and/or as an immunogen or vaccine to protect against infection by hepatitis E.
摘要翻译： 本发明涉及在真核表达系统中来自巴基斯坦（SAR-55）的乙型肝炎病毒株的开放阅读框2（ORF-2）蛋白的表达。 表达的蛋白质可以用作诊断免疫测定中的抗原和/或作为免疫原或疫苗以防止乙型肝炎的感染。
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公开(公告)号：US06287759B1
公开(公告)日：2001-09-11
申请号：US08471971
申请日：1995-06-06
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07H21/00 , C12N7/00 , C12N15/1131 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2710/14143 , C12N2770/28021 , C12N2770/28022 , C12N2770/28122 , C12N2770/28123 , Y10S977/802 , C12N2310/3521
摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
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9.发明授权Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines 失效巴基斯坦戊型肝炎病毒的重组蛋白及其在诊断方法和疫苗中的应用公开(公告)号：US06207416B1
公开(公告)日：2001-03-27
申请号：US08809523
申请日：1997-05-28
IPC分类号： C12N1551
CPC分类号： C07H21/00 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N15/1131 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2710/14143 , C12N2770/28021 , C12N2770/28022 , C12N2770/28122 , C12N2770/28123 , C12N2310/3521
摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
摘要翻译： 披露了一种来自巴基斯坦的丙型肝炎病毒（SAR-55），涉及到目前被称为戊型肝炎的非传染性非乙型肝炎的流行病。 本发明涉及真核表达系统中SAR-55整体结构域的表达，其命名为开放阅读框架2（ORF-2）。 表达的蛋白质能够形成HEV病毒样颗粒，其可以在诊断免疫测定中作为抗原，并作为免疫原或疫苗以防止乙型肝炎感染。
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10.发明授权Method for producing an adapted virus population from an African green monkey kidney cell line 失效从非洲绿猴肾细胞系生产适应病毒群体的方法
公开(公告)号：US6117667A
公开(公告)日：2000-09-12
申请号：US336740
申请日：1999-06-21
IPC分类号： C12N5/00 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/15 , A61K39/29 , A61P31/12 , C12N7/00 , C12N7/04 , C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , C12N2720/12351 , C12N2740/10051 , C12N2740/14051 , C12N2760/16151 , C12N2760/16251 , C12N2760/18551 , C12N2760/18651 , C12N2760/18751 , C12N2770/12051 , C12N2770/32351 , C12N2770/32451 , C12N2770/32651
摘要： The invention described herein provides a method for selecting a novel African Green monkey kidney (AGMK) cell substrate, its cultivation and serial passage and its subsequent characterization. The invention provides a method for the use of the cell substrate in the isolation, growth and serial passage of a large number of viruses, particularly rotaviruses, enteroviruses, respiratory viruses and hepatitis A virus. The invention provides a method for the utilization of this AGMK cell substrate for the production of live and killed virus vaccines.
摘要翻译： 本文描述的本发明提供了一种选择新型非洲绿猴肾（AGMK）细胞底物的方法，其培养和连续传代及其随后的表征。 本发明提供了在大量病毒，特别是轮状病毒，肠道病毒，呼吸道病毒和甲型肝炎病毒的分离，生长和连续传代中使用细胞底物的方法。 本发明提供了一种利用该AGMK细胞底物生产活的和杀死的病毒疫苗的方法。
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