Invention Grant
- Patent Title: Peptide inhibitors of calmodulin
- Patent Title (中): 钙调蛋白肽抑制剂
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Application No.: US660747Application Date: 1996-06-06
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Publication No.: US5840697APublication Date: 1998-11-24
- Inventor: Sylvie E. Blondelle , Richard A. Houghten , Enrique Perez-Paya
- Applicant: Sylvie E. Blondelle , Richard A. Houghten , Enrique Perez-Paya
- Applicant Address: CA San Diego
- Assignee: Torrey Pines Institute for Molecular Studies
- Current Assignee: Torrey Pines Institute for Molecular Studies
- Current Assignee Address: CA San Diego
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K7/06 ; A61K38/08
Abstract:
The present invention relates to novel family of peptides which inhibit calmodulin and which have the general structure Ac-A1-B2-C3-D4-E5-F6-NH.sub.2, (SEQ ID No. 1), wherein A1 is (D)Leu or Leu, B2 is (D)Gln, Gln, (D)Trp, or Trp, C3 is (D)Arg, Arg, (D)Ile, or Ile, D4 is (D)Ile, Ile, (D)His, or His, E5 is (D)Leu, Leu, (D)His, or His, and F6 is (D)Trp, Trp, (D)Arg, or Arg. The novel peptides can be used to inhibit the activity of calmodulin. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a calmodulin-inhibitor peptide. These compositions can be used to treat calmodulin related disorders.
Public/Granted literature
- US4617879A Fuel and oil mixture producing device for two-cycle engines Public/Granted day:1986-10-21
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