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67 条记录 (耗时 0.043 秒)

    Volatilizable solid phase supports for compound synthesis
    1.
    发明授权
    Volatilizable solid phase supports for compound synthesis 失效
    用于化合物合成的挥发性固相载体

    公开(公告)号：US06476191B1

    公开(公告)日：2002-11-05

    申请号：US09493902

    申请日：2000-01-28

    申请人： Jeanick H. Pascal ,  Michael J. Moran ,  Richard A. Houghten

    发明人： Jeanick H. Pascal ,  Michael J. Moran ,  Richard A. Houghten

    IPC分类号： C07K102

    CPC分类号： C07K7/06 ,  C07K1/04 ,  C07K1/042 ,  C07K7/08

    摘要： A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.

    摘要翻译： 公开了一种固相合成方法，其中进行通常的固相合成步骤，并且在将固相支持物从反相产物切割出来时，废固相载体反应形成可挥发化合物。 然后通过该化合物的挥发将裂解的产物与挥发性化合物分离。 还公开了形成可挥发化合物的示例性固体支持物。

    Linear substituted oligoalkyleneimine libraries
    5.
    发明授权
    Linear substituted oligoalkyleneimine libraries 失效
    线性取代的低聚亚烷基亚胺文库

    公开(公告)号：US06197529B1

    公开(公告)日：2001-03-06

    申请号：US08063279

    申请日：1993-05-18

    申请人： Richard A. Houghten ,  Julio Hernan Cuervo ,  Fred F. Weitl

    发明人： Richard A. Houghten ,  Julio Hernan Cuervo ,  Fred F. Weitl

    IPC分类号： G01N33567

    CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00725 ,  C40B40/10

    摘要： Linear substituted oligoalkyleneimine molecules and libraries of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a library contains the same number of 2 to about 10 substituted alkyleneimine repeating units, whose substituents are reduced amino acid side chains bonded to the repeating units at a position alpha to the nitrogen atom, and the member chains of a library are present in equimolar amounts. The chains of a library contain one or more predetermined reduced amino acid side chain-substituted repeating units at one or more predetermined positions of the substituted oligoalkyleneimine chain. The library contains equimolar amounts of at least six different reduced amino acid side chain-substituted repeating units at one or more of the same predetermined positions of the substituted oligoalkyleneimine chain. Particularly preferred linear substituted oligoalkyleneimine molecules and libraries are linear substituted oligoethyleneimines.

    摘要翻译： 公开了线性取代的低聚亚烷基亚胺分子和分子文库，以及其在受体结合测定中的合成和使用方法。 文库的每个分子或链包含相同数量的2至约10个取代的亚烷基亚胺重复单元，其取代基是与氮原子的α位置的键合到重复单元的还原氨基酸侧链，以及文库的成员链 以等摩尔量存在。 文库的链在取代的低聚亚烷基亚胺链的一个或多个预定位置含有一个或多个预定的还原氨基酸侧链取代的重复单元。 该文库在取代的低聚亚烷基亚胺链的一个或多个相同的预定位置包含等摩尔量的至少六个不同的还原氨基酸侧链取代的重复单元。 特别优选的线性取代的低聚亚烷基亚胺分子和文库是线性取代的低聚亚乙基亚胺。

    Peralkylated oligopeptide mixtures
    8.
    发明授权
    Peralkylated oligopeptide mixtures 失效
    过烷基化寡肽混合物

    公开(公告)号：US5763193A

    公开(公告)日：1998-06-09

    申请号：US577846

    申请日：1995-12-22

    申请人： Richard A. Houghten ,  John M. Ostresh ,  Sylvie Blondelle

    发明人： Richard A. Houghten ,  John M. Ostresh ,  Sylvie Blondelle

    IPC分类号： C07K1/04 ,  C07K1/12 ,  C12Q1/18 ,  G01N33/53

    CPC分类号： C07K1/04 ,  C07K1/12 ,  C12Q1/18

    摘要： Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides.

    摘要翻译： 公开了线性C 1 -C 7烷基全烷基化寡肽组分子，以及其在受体结合测定中的合成和使用方法。 一组的每个分子或链含有相同数量的两个至约十个取代的C 1 -C 7烷基全烷基化氨基酸残基，并且一组的成员链以等摩尔量存在。 一组的链在全烷基化寡肽链的一个或多个预定位置含有一个或多个预定的全烷基化氨基酸残基。 该组在全烷基化寡肽链的一个或多个相同的预定位置含有等摩尔量的至少六个不同的烷基化氨基酸残基。 这些组的文库，它们的使用方法和固体支持物连接的烷基化组也被考虑，特定的甲基化寡肽也是如此。

    Deletion and substitution analogues of melittin peptide
    10.
    发明授权
    Deletion and substitution analogues of melittin peptide 失效
    蜂毒肽的缺失和取代类似物

    公开(公告)号：US5235038A

    公开(公告)日：1993-08-10

    申请号：US643343

    申请日：1991-01-22

    申请人： Sylvie E. Blondelle ,  Richard A. Houghten

    发明人： Sylvie E. Blondelle ,  Richard A. Houghten

    IPC分类号： A61K38/00 ,  C07K14/435

    CPC分类号： C07K14/43572 ,  A61K38/00 ,  Y10S530/858

    摘要： A compound comprising an analogue of the melittin peptide having the following structural formula: ##STR1## wherein at least one and no more than four amino acid residues are omitted from the peptide, or at least one of amino acid residues 1-6, 8-18, or 20-26 in the peptide is substituted with a hydrophobic residue, provided that no more than two of amino acid residues 21-26 is substituted with a hydrophobic residue. Such deletion and substitution analogues are useful as antibiotics, antimicrobial agents, antifungal agents, anti-tumor agents, antiviral agents, or agents which stimulate wound healing.

    摘要翻译： 包含具有以下结构式的蜂毒肽的类似物的化合物：其中从肽中除去至少一个不超过四个氨基酸残基，或至少一个氨基酸（SEQ ID NO： 肽中的残基1-6,8-18或20-26被疏水残基取代，条件是不超过两个氨基酸残基21-26被疏水残基取代。 这种缺失和取代类似物可用作抗生素，抗微生物剂，抗真菌剂，抗肿瘤剂，抗病毒剂或刺激伤口愈合的药剂。