发明授权
- 专利标题： Isoxazoline and isoxazole fibrinogen receptor antagonists
- 专利标题（中）： 异恶唑啉和异恶唑纤维蛋白原受体拮抗剂
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申请号： US455436申请日： 1995-05-31
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公开(公告)号： US5849736A公开(公告)日： 1998-12-15
- 发明人: John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
- 申请人： John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
- 申请人地址： DE Wilmington
- 专利权人： The DuPont Merck Pharmaceutical Company
- 当前专利权人： The DuPont Merck Pharmaceutical Company
- 当前专利权人地址： DE Wilmington
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61K31/423 ; A61K31/425 ; A61K31/435 ; A61K31/44 ; A61K31/445 ; A61K31/47 ; A61K31/495 ; A61K31/496 ; A61K31/50 ; A61K31/505 ; A61K31/535 ; A61K31/5377 ; A61K31/55 ; A61K31/66 ; A61K31/665 ; A61K45/00 ; A61P1/00 ; A61P3/08 ; A61P3/10 ; A61P7/02 ; A61P7/04 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P17/00 ; A61P19/10 ; A61P27/02 ; A61P27/14 ; A61P29/00 ; A61P31/04 ; A61P35/00 ; A61P37/00 ; A61P37/08 ; A61P43/00 ; C07D261/04 ; C07D261/06 ; C07D261/10 ; C07D261/12 ; C07D261/18 ; C07D261/20 ; C07D413/04 ; C07D413/06 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D498/10 ; C07F7/10 ; C07F9/653 ; C07F9/6571 ; C07D261/02 ; A61K31/54 ; C07D217/00
摘要：
This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
公开/授权文献
- US6148771A Chew article for animals promoting dental/gingival health 公开/授权日：2000-11-21