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公开(公告)号:US6114328A
公开(公告)日:2000-09-05
申请号:US978295
申请日:1997-11-25
申请人: John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
发明人: John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/5377 , A61K31/55 , A61K31/66 , A61K31/665 , A61K45/00 , A61P1/00 , A61P3/08 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P19/10 , A61P27/02 , A61P27/14 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D261/04 , C07D261/06 , C07D261/10 , C07D261/12 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/10 , C07F7/10 , C07F9/653 , C07F9/6571 , A61K31/54 , C07D217/00 , C07D261/02
CPC分类号: C07D413/04 , C07D261/04 , C07D261/10 , C07D413/06 , C07D413/12
摘要: This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
摘要翻译: 本发明涉及可用作血小板糖蛋白IIb / IIIa纤维蛋白原受体复合物或玻连蛋白受体的拮抗剂的新的异恶唑和异恶唑,含有这些化合物的药物组合物,制备这些化合物的方法,以及单独使用这些化合物的方法 或与其它治疗剂组合,用于抑制血小板聚集,作为血栓溶解剂,和/或用于治疗血栓栓塞性疾病。
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公开(公告)号:US5849736A
公开(公告)日:1998-12-15
申请号:US455436
申请日:1995-05-31
申请人: John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
发明人: John Wityak , Chu-Biao Xue , Thais Motria Sielecki-Dzurdz , Richard Eric Olson , William Frank Degrado , Gary Avonn Cain , Douglas Guy Batt , Donald Pinto , Munir Alwan Hussain , Shaker Ahmed Mousa
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/5377 , A61K31/55 , A61K31/66 , A61K31/665 , A61K45/00 , A61P1/00 , A61P3/08 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P19/10 , A61P27/02 , A61P27/14 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D261/04 , C07D261/06 , C07D261/10 , C07D261/12 , C07D261/18 , C07D261/20 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/10 , C07F7/10 , C07F9/653 , C07F9/6571 , C07D261/02 , A61K31/54 , C07D217/00
CPC分类号: C07D413/04 , C07D261/04 , C07D261/10 , C07D413/06 , C07D413/12
摘要: This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
摘要翻译: 本发明涉及可用作血小板糖蛋白IIb / IIIa纤维蛋白原受体复合物或玻连蛋白受体的拮抗剂的新的异恶唑和异恶唑,含有这些化合物的药物组合物,制备这些化合物的方法,以及单独使用这些化合物的方法 或与其它治疗剂组合,用于抑制血小板聚集,作为血栓溶解剂,和/或用于治疗血栓栓塞性疾病。
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3.
公开(公告)号:US5739163A
公开(公告)日:1998-04-14
申请号:US612597
申请日:1996-03-08
IPC分类号: C07C217/22 , C07C225/16 , C07C279/10 , C07D295/112 , A61K31/495 , C07C229/38
CPC分类号: C07D295/112 , C07C217/22 , C07C225/16 , C07C279/10 , C07C2101/02
摘要: This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
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公开(公告)号:US6107300A
公开(公告)日:2000-08-22
申请号:US823029
申请日:1997-03-21
申请人: Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
发明人: Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
IPC分类号: C07D473/34 , A01N43/54 , A61K31/437 , A61K31/44 , A61K31/505 , A61K31/519 , A61K31/52 , A61P1/00 , A61P15/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P37/06 , A61P43/00 , C07D221/00 , C07D239/00 , C07D471/02 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: Corticotropin releasing factor (CRF) antagonists of formula I or formula II: ##STR1## and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
摘要翻译: 式I或式II的促肾上腺皮质激素释放因子(CRF)拮抗剂及其用于治疗焦虑,抑郁和其他精神和神经障碍的用途。
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公开(公告)号:US06448261B1
公开(公告)日:2002-09-10
申请号:US09525619
申请日:2000-03-14
申请人: Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
发明人: Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
IPC分类号: A61K3144
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: Corticotropin releasing factor (CRF) antagonists of formula I; and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
摘要翻译: 式I的促肾上腺皮质激素释放因子(CRF)拮抗剂;以及它们在治疗焦虑,抑郁和其他精神和神经障碍中的用途。
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公开(公告)号:US06239143B1
公开(公告)日:2001-05-29
申请号:US09344916
申请日:1999-06-25
IPC分类号: C07D21704
CPC分类号: C07D221/14 , C07D209/44 , C07D209/62 , C07D217/04 , C07D401/04 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06
摘要: The present invention relates to compounds having pharmacological activity toward the 5-HT7 receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.
摘要翻译: 本发明涉及对5-HT 7受体具有药理活性的化合物。 描述了其用于治疗CNS疾病的药物组合物和方法。
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公开(公告)号:US06486173B2
公开(公告)日:2002-11-26
申请号:US09801127
申请日:2001-03-07
IPC分类号: C07D21700
CPC分类号: C07D221/14 , C07D209/44 , C07D209/62 , C07D217/04 , C07D401/04 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06
摘要: The present invention relates to compounds having pharmacological activity toward the 5-HT7 receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.
摘要翻译: 本发明涉及对5-HT7受体具有药理活性的化合物。 描述了其用于治疗CNS疾病的药物组合物和方法。
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