发明授权
- 专利标题： Soluble CTLA4 molecules and uses thereof
- 专利标题（中）： 可溶性CTLA4分子及其用途
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申请号： US459818申请日： 1995-06-02
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公开(公告)号： US5851795A公开(公告)日： 1998-12-22
- 发明人: Peter S. Linsley , Jeffrey A. Ledbetter , Nitin K. Damle , William Brady , Peter A. Kiener
- 申请人： Peter S. Linsley , Jeffrey A. Ledbetter , Nitin K. Damle , William Brady , Peter A. Kiener
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： NY New York
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P37/02 ; C07K14/705 ; C07K14/715 ; C07K16/00 ; C07K16/28 ; C12P21/08 ; A61K38/02 ; A61K39/395
摘要：
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
公开/授权文献
- US4522594A Light shield for a dental handpiece 公开/授权日：1985-06-11
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