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公开(公告)号：US5968510A
公开(公告)日：1999-10-19
申请号：US725776
申请日：1996-10-04
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K39/395
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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公开(公告)号：US5885579A
公开(公告)日：1999-03-23
申请号：US889666
申请日：1997-07-08
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US5851795A
公开(公告)日：1998-12-22
申请号：US459818
申请日：1995-06-02
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K38/02 , A61K39/395
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US5977318A
公开(公告)日：1999-11-02
申请号：US488062
申请日：1995-06-07
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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公开(公告)号：US20090317397A1
公开(公告)日：2009-12-24
申请号：US12459291
申请日：2009-06-30
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US06641809B1
公开(公告)日：2003-11-04
申请号：US08219200
申请日：1994-03-29
IPC分类号： A61K3817
CPC分类号： C07K14/70532 , A61K38/00 , C07K14/705 , C07K14/70521 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2319/00 , G01N33/56972 , Y10S514/885 , Y10S530/866 , Y10S530/867 , Y10S530/868
摘要： The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C&ggr;1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
摘要翻译： 本发明将B7抗原鉴定为与T细胞上的CD28受体反应的配体。 描述了B7抗原和CD28受体的片段和衍生物，包括与编码部分人免疫球蛋白Cgamma1的氨基酸序列连接的与B7或CD28的细胞外结构域相对应的氨基酸序列的融合蛋白。 提供了使用B7抗原，其片段和衍生物以及CD28受体，其片段和衍生物以及与B7抗原和/或CD28受体反应的抗体和其它分子调节CD28阳性T细胞应答的方法，以及 由T细胞介导的免疫应答。 本发明还包括检测与介导细胞间粘附的细胞受体反应的配体的测定方法。
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7.发明授权Methods for treating cancer and infectious disease by blocking CTLA4-B7 interactions 失效通过阻断CTLA4-B7相互作用治疗癌症和传染病的方法公开(公告)号：US07311910B2
公开(公告)日：2007-12-25
申请号：US10461000
申请日：2003-06-13
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US5844095A
公开(公告)日：1998-12-01
申请号：US375390
申请日：1995-01-18
IPC分类号： A61K38/00 , C07K14/705 , C07K19/00
CPC分类号： C07K14/70521 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US06887471B1
公开(公告)日：2005-05-03
申请号：US09454651
申请日：1999-12-06
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , A61K38/17 , C12N15/12 , C12N15/63
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： This invention provides methods for regulating T cell interactions with B7 positive cells. Methods are provided for using B7 antigen, its fragments and derivatives reactive with CTLA4 receptor, to regulate CTLA4 positive T cell responses, and immune responses mediated by T cells.
摘要翻译： 本发明提供了调节与B7阳性细胞的T细胞相互作用的方法。 提供了使用B7抗原及其与CTLA4受体反应的衍生物调节CTLA4阳性T细胞应答和T细胞介导的免疫应答的方法。
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公开(公告)号：US5521288A
公开(公告)日：1996-05-28
申请号：US219116
申请日：1994-03-29
IPC分类号： A61K38/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N15/12 , G01N33/569 , C07K16/46 , C07H21/04 , C07K14/00
CPC分类号： C07K14/70532 , C07K14/705 , C07K14/70521 , C07K16/2803 , C07K16/2818 , C07K16/2827 , G01N33/56972 , A61K38/00 , C07K2317/73 , C07K2319/00 , Y10S514/885 , Y10S530/866 , Y10S530/867 , Y10S530/868
摘要： The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C.gamma.1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
摘要翻译： 本发明将B7抗原鉴定为与T细胞上的CD28受体反应的配体。 描述了B7抗原和CD28受体的片段和衍生物，包括与编码部分人免疫球蛋白Cγ1的氨基酸序列连接的与B7或CD28的细胞外结构域相对应的氨基酸序列的融合蛋白。 提供了使用B7抗原，其片段和衍生物以及CD28受体，其片段和衍生物以及与B7抗原和/或CD28受体反应的抗体和其它分子调节CD28阳性T细胞应答的方法，以及 由T细胞介导的免疫应答。 本发明还包括检测与介导细胞间粘附的细胞受体反应的配体的测定方法。
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