发明授权
- 专利标题： In vitro ligation of foreign DNA into large eukaryotic viruses
- 专利标题（中）： 将外源DNA体外连接成大型真核病毒
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申请号： US935812申请日： 1992-08-26
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公开(公告)号： US5866383A公开(公告)日： 1999-02-02
- 发明人: Bernard Moss , Michael J. Merchlinsky
- 申请人： Bernard Moss , Michael J. Merchlinsky
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K14/02 ; C07K14/035 ; C07K14/07 ; C12N9/10 ; C12N15/863 ; C12N15/00 ; C12N7/01 ; C12N15/86
摘要：
In a preferred embodiment of the invention, methods are provided for the production of viral vectors from large viral genomes (greater than 50 kbp) that incorporate nucleic acid insertions by direct in vitro ligation. In another preferred embodiment of this invention, viral vectors are provided from large viral genomes. These viral vectors accommodate nucleic acid inserts by direct in vitro ligation and facilitate the expression of foreign protein in eukaryotic cell systems.
公开/授权文献
- US5986142A Process for preparing bicycloheptanamine compounds 公开/授权日：1999-11-16
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