发明授权
US5889150A Expression-cloning method for identifying target proteins for eukaryotic
tyrosine kinases and novel target protiens
失效
用于鉴定真核酪氨酸激酶和新靶标物质的靶蛋白的表达克隆方法
- 专利标题： Expression-cloning method for identifying target proteins for eukaryotic tyrosine kinases and novel target protiens
- 专利标题（中）： 用于鉴定真核酪氨酸激酶和新靶标物质的靶蛋白的表达克隆方法
-
申请号： US252820申请日： 1994-06-02
-
公开(公告)号： US5889150A公开(公告)日： 1999-03-30
- 发明人: Joseph Schlessinger , Edward Y. Skolnik , Benjamin L. Margolis , Harald App
- 申请人： Joseph Schlessinger , Edward Y. Skolnik , Benjamin L. Margolis , Harald App
- 申请人地址： NY New York
- 专利权人： New York University Medical Center
- 当前专利权人： New York University Medical Center
- 当前专利权人地址： NY New York
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/47 ; C07K14/475 ; C07K14/705 ; C07K14/71 ; C07K16/28 ; C12N15/12 ; C07K14/205
摘要：
The present invention relates to a novel method, based on direct expression cloning, for identifying target proteins capable of binding to and/or serving as substrates for receptor or cytoplasmic tyrosine kinases. The present invention also relates to novel proteins identified using this method, and to methods for identifying compounds that disrupt the interaction of such novel proteins with the receptor or cytoplasmic tyrosine kinases.