发明授权
US5900402A Method of reducing side effects associated with administration of
oxygen-carrying proteins
失效
降低与携带携带蛋白质的给药相关的副作用的方法
- 专利标题： Method of reducing side effects associated with administration of oxygen-carrying proteins
- 专利标题（中）： 降低与携带携带蛋白质的给药相关的副作用的方法
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申请号： US865035申请日： 1997-05-29
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公开(公告)号： US5900402A公开(公告)日： 1999-05-04
- 发明人: Robert G. L. Shorr
- 申请人： Robert G. L. Shorr
- 申请人地址： NJ Piscataway
- 专利权人： Enzon, Inc.
- 当前专利权人： Enzon, Inc.
- 当前专利权人地址： NJ Piscataway
- 主分类号： A61K38/42
- IPC分类号： A61K38/42 ; A61K47/48 ; A01N37/18 ; A61K38/16 ; C07K14/00 ; C07K16/00
摘要：
A method of reducing side-effects associated with administering oxygen-carrying proteins to mammals is disclosed. The method includes:a) reacting an oxygen-carrying protein with a substantially non-antigenic polymer to form a oxygen-carrying protein-substantially non-antigenic polymer conjugate; andb) administering the oxygen-carrying protein-substantially non-antigenic polymer conjugate to a mammal in need of the oxygen-carrying protein. Preferred oxygen-carrying proteins include recombinantly prepared hemoglobins and preferred non-antigenic polymers include polyethylene glycol.
公开/授权文献
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