- 专利标题： Reagent useful for synthesizing sulfurized oligonucleotide analogs
-
申请号： US811233申请日： 1997-03-03
-
公开(公告)号： US5902881A公开(公告)日： 1999-05-11
- 发明人: Zacharia S. Cheruvallath , Vasulinga T. Ravikumar , Douglas L. Cole , Daniel C. Capaldi
- 申请人： Zacharia S. Cheruvallath , Vasulinga T. Ravikumar , Douglas L. Cole , Daniel C. Capaldi
- 申请人地址： CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： CA Carlsbad
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07C329/14 ; C07H21/00 ; C07H21/02
摘要：
The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
公开/授权文献
- US4672116A Substituted 5,6-dialkoxyquinazoline derivatives 公开/授权日：1987-06-09
信息查询
