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公开(公告)号：US07186822B2
公开(公告)日：2007-03-06
申请号：US11025791
申请日：2004-12-28
Applicant: Vasulinga Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei P. Guzaev
Inventor： Vasulinga Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei P. Guzaev
IPC: C07H21/00
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
Abstract translation: 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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公开(公告)号：US5902881A
公开(公告)日：1999-05-11
申请号：US811233
申请日：1997-03-03
Applicant: Zacharia S. Cheruvallath , Vasulinga T. Ravikumar , Douglas L. Cole , Daniel C. Capaldi
IPC: C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC classification number: C07H21/00 , C07C329/14
Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
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公开(公告)号：US07446193B2
公开(公告)日：2008-11-04
申请号：US11670283
申请日：2007-02-01
Applicant: Patrick Wheeler , Daniel C. Capaldi
Inventor： Patrick Wheeler , Daniel C. Capaldi
CPC classification number: C07H21/00 , G01N24/08 , G01R33/44 , G01R33/46 , Y10T436/193333 , Y10T436/196666
Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
Abstract translation: 描述了检测二氯乙酸中水合氯醛的方法。
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公开(公告)号：US07041816B2
公开(公告)日：2006-05-09
申请号：US10760940
申请日：2004-01-20
Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Inventor： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC: C07H21/00
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US06335439B1
公开(公告)日：2002-01-01
申请号：US09095811
申请日：1998-06-11
Applicant: Alessandra Eleuteri , Daniel C. Capaldi , Vasulinga T. Ravikumar
Inventor： Alessandra Eleuteri , Daniel C. Capaldi , Vasulinga T. Ravikumar
IPC: C07H102
Abstract: Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.
Abstract translation: 公开了改进的亚磷酰胺化合物的制备方法。 亚磷酰胺可用于例如通过固态寡核苷酸合成方案制备寡核苷酸。
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Patent Agency Ranking
公开(公告)号：US5959099A
公开(公告)日：1999-09-28
申请号：US103399
申请日：1998-06-24
Applicant: Zacharia S. Cheruvallath , Daniel C. Capaldi , Vasulinga T. Ravikumar , Douglas L. Cole
IPC: C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H19/04
CPC classification number: C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
Abstract: A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
Abstract translation: 式（1）的2-N-酰氨基保护的核苷类似物亚磷酰胺：可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中，亚磷酰胺（1）的偶联产率高，在标准条件下可以容易地除去2-N-酰氨基乙基保护基。
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公开(公告)号：US07199236B2
公开(公告)日：2007-04-03
申请号：US10940360
申请日：2004-09-14
Applicant: Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
Inventor： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC: C07H21/00
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US06649750B1
公开(公告)日：2003-11-18
申请号：US09477878
申请日：2000-01-05
Applicant: Daniel C. Capaldi , Vasulinga T. Ravikumar , Douglas L. Cole
Inventor： Daniel C. Capaldi , Vasulinga T. Ravikumar , Douglas L. Cole
IPC: C07H2100
CPC classification number: C07H21/00 , C07B2200/11
Abstract: Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
Abstract translation: 提供了合成方法，其中使用支持结合的亚磷酰胺方案制备高纯度低聚物，起始于通过核苷酸杂环碱基部分与支持介质连接的核苷或更大的合成子。 在洗涤循环期间，在载体连接位点处经历去血的中间体被去除。 还提供了可用于这些方法的组合物。
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公开(公告)号：US6160152A
公开(公告)日：2000-12-12
申请号：US414145
申请日：1999-10-07
Applicant: Daniel C. Capaldi , Vasulinga T. Ravikumar
Inventor： Daniel C. Capaldi , Vasulinga T. Ravikumar
CPC classification number: C07H21/00
Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.
Abstract translation: 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯和二硫代磷酸酯共价键的低聚化合物。 还提供了可用于这些方法的合成中间体。
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公开(公告)号：US07759480B2
公开(公告)日：2010-07-20
申请号：US11668174
申请日：2007-01-29
Applicant: Achim Krotz , Daniel C. Capaldi , Hans-Joachim Josef Gaus , Brett Turney
Inventor： Achim Krotz , Daniel C. Capaldi , Hans-Joachim Josef Gaus , Brett Turney
IPC: C07H21/00
CPC classification number: C07H21/00
Abstract: A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
Abstract translation: 制造寡核苷酸的方法包括5-去封闭步骤，其中5-封闭基团用基本上不含氯醛的二氯乙酸除去。 该方法可用于制备基本上不含氯醛加合物的寡核苷酸。
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