发明授权
- 专利标题： 8-substituted quinazolines, quinoxalines and benzopyridazines
- 专利标题（中）： 8-取代喹唑啉，喹喔啉和苯并哒嗪
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申请号： US933354申请日： 1997-09-19
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公开(公告)号： US5922711A公开(公告)日： 1999-07-13
- 发明人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
- 申请人： Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
- 申请人地址： JPX Osaka
- 专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： GBX9308804 19930428; GBX9318929 19930913
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/495 ; A61K31/498 ; A61K31/50 ; A61K31/502 ; A61K31/505 ; A61K31/517 ; A61K31/53 ; A61P35/00 ; A61P37/08 ; A61P43/00 ; C07D215/24 ; C07D215/26 ; C07D215/40 ; C07D237/10 ; C07D237/28 ; C07D239/74 ; C07D241/42 ; C07D241/44 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D409/12 ; C07D413/12 ; C07F7/18 ; C07D239/72 ; C07D241/40
摘要：
A compound of the formula: ##STR1## wherein --X.sup.3 .dbd.X.sup.2 --X.sup.1 .dbd.N-- is a group of the formula: ##STR2## R.sup.1 is hydrogen or halogen, R.sup.2 is halogen,R.sup.3 is hydrogen, nitro, amino optionally having at least one substituent or a heterocyclic group optionally having at least one substituent,R.sup.4 and R.sup.5 are each hydrogen, or halogen,R.sup.6 and R.sup.8 are each hydrogen, halogen, lower alkyl, hydroxy, lower alkylthio, amino optionally substituted with lower alkyl, or lower alkoxy optionally substituted with a substituent selected from the group consisting of hydroxy, lower alkoxy, amino, lower alkylamino and aryl optionally substituted with lower alkoxy,R.sup.7 is hydrogen or lower alkyl,A is lower alkylene, andQ is O or N--R.sup.9 is hydrogen or acyl,provided that R.sup.3 is not hydrogen when X.sup.1 is C--R.sup.6, in which R.sup.6 is hydrogen, andpharmaceutically acceptable salts thereof.
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