发明授权
US5935789A Autonomously replicating sequences, GAPDH gene and promoter derived from
Hansenula polymorpha, expression vectors containing same and method for
the selection of transformants
失效
自主复制序列，GAPDH基因和源自多形汉逊酵母的启动子，含有相同的表达载体和选择转化体的方法
- 专利标题： Autonomously replicating sequences, GAPDH gene and promoter derived from Hansenula polymorpha, expression vectors containing same and method for the selection of transformants
- 专利标题（中）： 自主复制序列，GAPDH基因和源自多形汉逊酵母的启动子，含有相同的表达载体和选择转化体的方法
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申请号： US903800申请日： 1997-07-31
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公开(公告)号： US5935789A公开(公告)日： 1999-08-10
- 发明人: Sang-Ki Rhee , Eui-Sung Choi , Chul-Ho Kim , Jung-Hoon Sohn , Hyun-Ah Kang , Hwa-Young Kim
- 申请人： Sang-Ki Rhee , Eui-Sung Choi , Chul-Ho Kim , Jung-Hoon Sohn , Hyun-Ah Kang , Hwa-Young Kim
- 申请人地址： KRX Seoul
- 专利权人： Korea Institute of Science and Technology
- 当前专利权人： Korea Institute of Science and Technology
- 当前专利权人地址： KRX Seoul
- 优先权： KRX97-3173 19970131
- 主分类号： C07K14/485
- IPC分类号： C07K14/485 ; C12N1/19 ; C12N9/02 ; C12N15/81 ; C12Q1/68 ; C12N9/72
摘要：
Autonomously replicating sequences(ARS), glyceraldehyde-3-phosphate dehydrogenase(GAPDH) gene and GAPDH promoter derived from Hansenula polymorpha DL-1(ATCC 26012); a vector for H. polymorpha which contains the novel ARS and is capable of inserting tandem repeating multiple copies of a polynucleotide encoding a foreign protein to the chromosome of H. polymorpha; a process for the production of a foreign protein in H. polymorpha by employing said vector; and a method for the selection of transformed H. polymorpha having multiple copies of integrated foreign genes.
公开/授权文献
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