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480 条记录 (耗时 0.028 秒)

    Self-assembling synthetic proteins
    1.
    发明授权
    Self-assembling synthetic proteins 有权

    公开(公告)号：US11419923B2

    公开(公告)日：2022-08-23

    申请号：US16843118

    申请日：2020-04-08

    申请人： In3Bio Ltd.

    发明人： Keith Alan Charlton ,  Erik D'Hondt ,  Daniel T. Verhamme

    IPC分类号： A61K39/00 ,  C07K14/475 ,  C07K14/485 ,  C07K14/495 ,  C07K14/50

    摘要： The present disclosure provides for a synthetic immunogenic protein for use as an immuno-modulatory agent to enhance mammalian immune reactions towards conjugated protein or peptide containing antigens that are otherwise poorly immunogenic, including but not limited to self-antigens. The chimeric immunogenic proteins of the present disclosure can be used in the treatment of many illnesses, including but not limited to cancers, infectious disease, autoimmune disease, allergies and any clinical indication involving or affected by the immune response of a mammalian host.

    Multivalent heteromultimer scaffold design and constructs
    4.
    发明授权
    Multivalent heteromultimer scaffold design and constructs 有权

    公开(公告)号：US11248037B2

    公开(公告)日：2022-02-15

    申请号：US16417969

    申请日：2019-05-21

    申请人： Zymeworks Inc.

    发明人： Surjit Bhimarao Dixit ,  Igor Edmondo Paolo D'Angelo ,  Mario Sanches ,  Gordon Yiu Kon Ng

    IPC分类号： C07K14/765 ,  C07K16/28 ,  C07K14/76 ,  C07K16/00 ,  C07K14/485 ,  C07K14/605 ,  C07K16/40

    摘要： Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species.

    Ca2+ regulated binding agents
    7.
    发明授权
    Ca2+ regulated binding agents 有权

    公开(公告)号：US11078255B2

    公开(公告)日：2021-08-03

    申请号：US16550803

    申请日：2019-08-26

    申请人： SYMTHERA CANADA LTD.

    发明人： Chai Ezerzer

    IPC分类号： C07K14/71 ,  C07K14/47 ,  G01N33/74 ,  C07K14/485

    摘要： Disclosed are binding agents that include (a) a calcium binding portion which includes an F-helix peptide and a calcium binding loop peptide derived from an EF-hand motif of a calcium binding protein, wherein the C-terminus of the F-helix peptide is covalently linked to the N-terminus of the calcium binding loop peptide by a peptide bond, and (b) a targeting peptide, wherein the N-terminus of the targeting peptide is covalently linked to the C-terminus of the calcium binding portion by a peptide bond. The binding agents can be used for diagnosis and treatment of various disorders.

    MODIFIED EGF PROTEIN, PRODUCTION METHOD THEREFOR, AND USE THEREOF
    8.
    发明申请
    MODIFIED EGF PROTEIN, PRODUCTION METHOD THEREFOR, AND USE THEREOF 有权

    公开(公告)号：US20210188931A1

    公开(公告)日：2021-06-24

    申请号：US16757823

    申请日：2018-10-23

    申请人： PROGEN CO., LTD.

    发明人： Zungyoon YANG ,  Eun Joo NAM

    IPC分类号： C07K14/485 ,  C12P21/02 ,  A61K8/64 ,  A61Q19/00

    摘要： A modified EGF protein, a production method therefor, and a use thereof are disclosed. The modified EGF protein allows an effective delivery of EGF into the cell and exhibits an enhanced half-life span. A method for producing the modified EGF protein includes culturing conditions where host cell growth phase and protein expression phase employ different temperature conditions. A use of the modified EGF protein is also disclosed.