发明授权
- 专利标题： DNA vaccination for induction of suppressive T cell response
- 专利标题（中）： 用于诱导抑制性T细胞应答的DNA疫苗接种
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申请号： US606639申请日： 1996-02-26
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公开(公告)号： US5939400A公开(公告)日： 1999-08-17
- 发明人: Lawrence Steinman , Ari Waisman
- 申请人： Lawrence Steinman , Ari Waisman
- 申请人地址： CA Palo Alto
- 专利权人： The Board of Trustees of The Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of The Leland Stanford Junior University
- 当前专利权人地址： CA Palo Alto
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/00 ; A61K31/70 ; A61K31/7088 ; A61K31/711 ; A61K38/00 ; A61K48/00 ; A61P29/00 ; A61P37/00 ; A61P37/06 ; C07K14/725 ; C12Q1/68 ; A01N43/04 ; C12N15/00 ; C12N15/63
摘要：
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.