发明授权
US5942619A Quinolone compounds for the treatment of disorders caused by
helicobacter pylori
失效
喹诺酮化合物用于治疗由幽门螺杆菌引起的疾病
- 专利标题： Quinolone compounds for the treatment of disorders caused by helicobacter pylori
- 专利标题（中）： 喹诺酮化合物用于治疗由幽门螺杆菌引起的疾病
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申请号： US43374申请日： 1998-04-24
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公开(公告)号： US5942619A公开(公告)日： 1999-08-24
- 发明人: Koenraad A. Dekker , Liang H. Huang , Taisuke Inagaki , Nakao Kojima , Yasuhiro Kojima , Yuji Yamauchi
- 申请人： Koenraad A. Dekker , Liang H. Huang , Taisuke Inagaki , Nakao Kojima , Yasuhiro Kojima , Yuji Yamauchi
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 优先权： WOXPCT/IB95/00812 19950929
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P1/04 ; A61P1/14 ; A61P31/04 ; C07D215/22 ; C07D215/233 ; C07D405/06 ; C12N1/14 ; C12N1/15 ; C12N1/20 ; C12P17/12 ; C12R1/01
摘要：
This invention provides processes for producing quinolone compounds which comprise cultivating Amycoa sp. FERM BP-4785, and then isolating quinolone compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I) wherein R.sup.1 is H, R.sup.2 is (a) and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.3, R.sup.2 is (a) and R.sup.3 is CH.sub.3 ; or R.sup.1 is CH.sub.3, R.sup.2 is (b) and R.sup.3 is CH.sub.3 ; and the like. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions caused thereby. ##STR1##
公开/授权文献
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