发明授权
US5948898A Methoxyethoxy oligonucleotides for modulation of protein kinase C
expression
失效
用于调节蛋白激酶C表达的甲氧基乙氧基寡核苷酸
- 专利标题： Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
- 专利标题（中）： 用于调节蛋白激酶C表达的甲氧基乙氧基寡核苷酸
-
申请号： US601269申请日： 1996-02-14
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公开(公告)号： US5948898A公开(公告)日： 1999-09-07
- 发明人: Nicholas M. Dean , Pierre Martin , Karl-Heinz Altmann
- 申请人： Nicholas M. Dean , Pierre Martin , Karl-Heinz Altmann
- 申请人地址： CA Carlsbad CHX Basel
- 专利权人： ISIS Pharmaceuticals, Inc.,Ciba-Geigy AG
- 当前专利权人： ISIS Pharmaceuticals, Inc.,Ciba-Geigy AG
- 当前专利权人地址： CA Carlsbad CHX Basel
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/00 ; A61K31/70 ; A61K31/7088 ; A61K31/712 ; A61K38/00 ; A61K48/00 ; A61P17/00 ; A61P17/06 ; A61P29/00 ; A61P35/00 ; C07H21/00 ; C12N9/12 ; C12N15/113 ; C12Q1/68 ; C07H21/04
摘要：
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
公开/授权文献
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