发明授权
- 专利标题： Tetrahydroisoquinoline derivatives
- 专利标题（中）： 四氢异喹啉衍生物
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申请号： US8724申请日： 1998-01-19
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公开(公告)号： US5952344A公开(公告)日： 1999-09-14
- 发明人: Alexander Alanine , Anne Bourson , Bernd Buttelmann , Gunther Fischer , Marie-Paule Heitz Neidhart , Vincent Mutel , Emmanuel Pinard , Stephan Rover , Gerhard Trube , Rene Wyler
- 申请人： Alexander Alanine , Anne Bourson , Bernd Buttelmann , Gunther Fischer , Marie-Paule Heitz Neidhart , Vincent Mutel , Emmanuel Pinard , Stephan Rover , Gerhard Trube , Rene Wyler
- 申请人地址： NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： NJ Nutley
- 优先权： EPX96101553 19960203
- 主分类号： C07D217/16
- IPC分类号： C07D217/16 ; A61K31/47 ; A61K31/472 ; A61K31/473 ; A61K31/4741 ; A61P25/00 ; A61P25/14 ; A61P25/16 ; A61P25/18 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P43/00 ; C07D217/18 ; C07D217/20 ; C07D217/24 ; C07D221/00 ; C07D221/06 ; C07D221/12 ; C07D491/04 ; C07D491/056
摘要：
The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula ##STR1## wherein A is arylR.sup.1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R--CO-- or R--COO--, wherein R is lower alkyl;R.sup.2 is hydrogen, lower alkyl or cycloalkylR.sup.3 -R.sup.7 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy orR.sup.3 and R.sup.4 taken together are --(CH.sub.2).sub.n -- orR.sup.6 and R.sup.7 taken together are --OCH.sub.2 O-- andn is 3 or 4,as well as pharmaceutically acceptable salts for the manufacture of medicaments for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.
公开/授权文献
- USD354481S Photomagnetic disc reader 公开/授权日：1995-01-17
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