发明授权
US5955476A Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method
of reducing inflammatory cytokine levels
失效
取代的2-(2,6-二氧代-3-氟哌啶-3-基) - 异吲哚啉和降低炎症细胞因子水平的方法
- 专利标题: Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
- 专利标题(中): 取代的2-(2,6-二氧代-3-氟哌啶-3-基) - 异吲哚啉和降低炎症细胞因子水平的方法
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申请号: US42274申请日: 1998-03-13
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公开(公告)号: US5955476A公开(公告)日: 1999-09-21
- 发明人: George W. Muller , David I. Stirling , Roger Shen-Chu Chen , Hon-Wah Man
- 申请人: George W. Muller , David I. Stirling , Roger Shen-Chu Chen , Hon-Wah Man
- 申请人地址: NJ Warren
- 专利权人: Celgene Corporation
- 当前专利权人: Celgene Corporation
- 当前专利权人地址: NJ Warren
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61K31/4439 ; A61K31/445 ; A61K31/452 ; A61K31/4523 ; A61P17/06 ; A61P19/02 ; A61P29/00 ; A61P31/08 ; A61P31/10 ; A61P33/06 ; A61P35/00 ; A61P43/00 ; C07D20060101 ; C07D401/04
摘要:
1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3 -yl)-isoindoline.
公开/授权文献
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