A thermal transfer sheet of the present invention has a heat resistant layer disposed on a back surface thereof and a slip layer disposed on the heat resistant layer. The heat resistant layer contains a binder resin having a molecular structure, one end portion of which is an end group selected from the group consisting of hydroxyl, amino, carboxyl and mercapto. The slip layer contains silylisocyanate represented by the following formula (1): R.sub.n --Si--(N C O).sub.4-n �in the formula (1), R denotes alkyl, aryl or vinyl; and "n" denotes an integer of 0 to 3!. The slip layer is hardened by reacting an isocyanate group of the silylisocyanate contained therein with the end group of the binder resin contained in the heat resistant layer.