发明授权
- 专利标题: N-benzylazolium derivatives
- 专利标题(中): N-苄基唑衍生物
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申请号: US226987申请日: 1999-01-08
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公开(公告)号: US5962686A公开(公告)日: 1999-10-05
- 发明人: Shigeyasu Ichihara , Chikako Murasaki , Noriko Ohga , Jun Ohwada , Daisuke Sawada , Nobuo Shimma , Michio Shirai , Isao Umeda
- 申请人: Shigeyasu Ichihara , Chikako Murasaki , Noriko Ohga , Jun Ohwada , Daisuke Sawada , Nobuo Shimma , Michio Shirai , Isao Umeda
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: EPX96114390 19960909; EPX97114246 19970818
- 主分类号: C07D249/08
- IPC分类号: C07D249/08 ; A61K31/00 ; A61K31/41 ; A61K31/415 ; A61K31/425 ; A61K31/495 ; A61P31/00 ; A61P31/04 ; A61P31/10 ; C07D233/60 ; C07D405/06 ; C07D407/10 ; C07D417/06 ; C07D417/10 ; C07D521/00 ; C07D405/14
摘要:
N-Benzylazolium derivatives of the general formula (I), ##STR1## wherein Q is the remainder of an azole compound of the formula II ##STR2## possessing antifungal activity; Z is nitrogen or methine;R.sup.1 and R.sup.2 are each independently a hydrogen atom or a group --OY �in which Y is a group easily hydrolyzable under physiological condition!;R.sup.3 and R.sup.4 are each independently a hydrogen or halogen atom, lower alkyl, lower alkoxy, lower alkylthio, (lower alkylcarbonyl)thiomethyl, carboxy or methoxycarbonyl; andX.sup.- is a pharmaceutically acceptable anion,as well as salts, hydrates or solvates of the compounds of the general formula (I) have antiftngal properties.
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