发明授权
- 专利标题： Purified bradykinin B.sub.1 receptor
- 专利标题（中）： 纯化缓激肽B1受体
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申请号： US932761申请日： 1997-09-17
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公开(公告)号： US5965367A公开(公告)日： 1999-10-12
- 发明人: David L. Linemeyer , John W. Hess , Joseph A. Borkowski , Kathleen K. Bierilo , John G. Menke
- 申请人： David L. Linemeyer , John W. Hess , Joseph A. Borkowski , Kathleen K. Bierilo , John G. Menke
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K45/00 ; A61K48/00 ; A61P9/02 ; A61P25/04 ; A61P29/00 ; A61P43/00 ; C07K14/72 ; C07K16/28 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12Q1/00 ; C12Q1/68 ; G01N33/53
摘要：
DNAs encoding bradykinin B.sub.1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg.sup.10 kallidin and other B.sub.1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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