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公开(公告)号：US5965367A
公开(公告)日：1999-10-12
申请号：US932761
申请日：1997-09-17
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/00 , C12Q1/68 , G01N33/53
摘要： DNAs encoding bradykinin B.sub.1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg.sup.10 kallidin and other B.sub.1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 从哺乳动物细胞编码缓激肽B1受体的DNA被克隆和表征。 重组受体能够形成结合des-Arg10刺球蛋白和其他B1特异性配体的受体。 DNA已经在产生活性重组蛋白的重组宿主细胞中表达。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06307027B1
公开(公告)日：2001-10-23
申请号：US09307912
申请日：1999-05-10
IPC分类号： C07K1628
摘要： DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind desArg10 kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 从哺乳动物细胞编码缓激肽B1受体的DNA被克隆和表征。 重组受体能够形成结合desArg10刺球蛋白和其他B1特异性配体的受体。 DNA已经在产生活性重组蛋白的重组宿主细胞中表达。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06407207B1
公开(公告)日：2002-06-18
申请号：US08148708
申请日：1993-11-08
IPC分类号： C07K14705
CPC分类号： C07K14/72 , A61K38/00 , C07K14/723
摘要： The present invention is a cloned human BK-2 bradykinin receptor cloned from a human lung fibroblast cell line. A cDNA clone, also part of the instant invention, encodes a novel 364 amino acid protein (the BK-2 receptor) that has the characteristics of a seven transmembrane domain G-protein coupled receptor. The invention is used to express a BK-2 bradykinin receptor in a host mammalian cell to screen for pharmaceutical antagonists or agonists which bind to or interact with the BK-2 bradykinin receptor protein.
摘要翻译： 本发明是从人肺成纤维细胞系克隆的克隆人BK-2缓激肽受体。 cDNA克隆也是本发明的一部分，编码具有七个跨膜结构域G蛋白偶联受体特征的新型364氨基酸蛋白（BK-2受体）。 本发明用于在宿主哺乳动物细胞中表达BK-2缓激肽受体，以筛选与BK-2缓激肽受体蛋白结合或相互作用的药物拮抗剂或激动剂。
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公开(公告)号：US5712111A
公开(公告)日：1998-01-27
申请号：US229418
申请日：1994-04-15
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/00 , C12N15/12
摘要： DNAs encoding bradykinin B.sub.1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg.sup.10 kallidin and other B.sub.1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US5750826A
公开(公告)日：1998-05-12
申请号：US759848
申请日：1996-12-02
申请人： Joseph A. Borkowski , Howard Y. Chen , John W. Hess , Catherine D. Strader , Myrna E. Trumbauer
发明人： Joseph A. Borkowski , Howard Y. Chen , John W. Hess , Catherine D. Strader , Myrna E. Trumbauer
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , C07K14/72 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A01K2267/0368
摘要： A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.
摘要翻译： 通过将编码改变的缓激肽B2受体的基因导入宿主非人动物来制备具有缓激肽B2受体基因改变的转基因非人动物。
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