发明授权
US5972646A Isolated nucleic acid molecule which codes for a 32 kDa protein having
11-cis retinol dehydrogenase activity, and which associates with P63, a
portion of a retinol binding protein receptor
失效
编码具有11-顺式视黄醇脱氢酶活性的32kDa蛋白质的分离的核酸分子，其与P63相结合，一部分视黄醇结合蛋白受体
- 专利标题： Isolated nucleic acid molecule which codes for a 32 kDa protein having 11-cis retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor
- 专利标题（中）： 编码具有11-顺式视黄醇脱氢酶活性的32kDa蛋白质的分离的核酸分子，其与P63相结合，一部分视黄醇结合蛋白受体
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申请号： US562114申请日： 1995-11-22
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公开(公告)号： US5972646A公开(公告)日： 1999-10-26
- 发明人: Ulf Eriksson , Andras Simon , Anna Romert
- 申请人： Ulf Eriksson , Andras Simon , Anna Romert
- 申请人地址： NY New York
- 专利权人： Ludwig Institute for Cancer Research
- 当前专利权人： Ludwig Institute for Cancer Research
- 当前专利权人地址： NY New York
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K49/00 ; C07K14/47 ; C07K16/18 ; C12N1/21 ; C12N5/10 ; C12N9/02 ; C12N9/04 ; C12N15/02 ; C12N15/09 ; C12N15/12 ; C12P21/08 ; C12Q1/68 ; C12R1/19 ; C12R1/91 ; G01N33/53 ; G01N33/577 ; C12N15/52 ; C12N15/63
摘要：
In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has been discovered. This protein, referred to an "p32," forms an oligomeric protein complex with the previously characterized p63 protein, a component of the membrane receptor for RBP. A nucleic acid molecule which codes for the p32 protein has also been isolated and sequence analysis shows that the p32 protein belongs to the family of short chain alcohol dehydrogenases, and exhibits 11-cis retinol dehydrogenase activity, the enzyme which catalyzes conversion of 11-cis-retinol into 11-cis retinaldehyde.
公开/授权文献
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