发明授权
- 专利标题: Basic protein composition, basic peptide composition and application thereof
- 专利标题(中): 碱性蛋白质组成,碱性肽组成及应用
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申请号: US785326申请日: 1997-01-21
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公开(公告)号: US5976597A公开(公告)日: 1999-11-02
- 发明人: Yukihiro Takada , Seiichiro Aoe , Hiroaki Matsuyama , Ken Kato , Junichi Yamamura
- 申请人: Yukihiro Takada , Seiichiro Aoe , Hiroaki Matsuyama , Ken Kato , Junichi Yamamura
- 申请人地址: JPX Tokyo
- 专利权人: Fujino Patent Attorney
- 当前专利权人: Fujino Patent Attorney
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX8-028459 19960123
- 主分类号: A21D2/26
- IPC分类号: A21D2/26 ; A23C9/146 ; A23C19/08 ; A23C19/082 ; A23J1/20 ; A23J3/08 ; A23J3/34 ; A23K1/16 ; A23K1/18 ; A23L1/06 ; A23L1/305 ; A23L2/66 ; A61K31/00 ; A61K38/00 ; A61K38/01 ; A61P3/02 ; A61P7/00 ; A61P19/00 ; A61P37/00 ; A61P43/00 ; C07K1/12 ; C07K1/18 ; C07K1/34 ; C07K14/47 ; C07K14/51 ; C12S3/24 ; A23C1/00 ; A23C7/04 ; A23C9/14
摘要:
The present invention provides a basic protein and a basic peptide composition which can be administered orally and has the ability to stimulate osteoblast proliferation, strengthen bone and inhibit bone resorption. Said basic protein has the following properties: (1) a molecular weight distribution of is 2,000-24,000; (2) an isoelectric point distribution of is 7.5-11; and (3) it is comprised of more than 10% of basic amino acids. Said composition can be obtained by the following steps: After milk, or raw material derived from milk, is loaded onto a cation exchange resin column, a fraction is obtained by eluting with an eluent of 0.1-1.0M salt concentration, precipitate removed by (i) heating to over 75.degree. C., (ii) by adding alcohol so that the final concentration thereof is 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatant thereof containing the basic protein fraction recovered.
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