发明授权
- 专利标题： Self-assembling polynucleotide delivery method
- 专利标题（中）： 自组装多核苷酸递送方法
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申请号： US480446申请日： 1995-06-07
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公开(公告)号： US5977084A公开(公告)日： 1999-11-02
- 发明人: Francis C. Szoka, Jr. , Jean Haensler
- 申请人： Francis C. Szoka, Jr. , Jean Haensler
- 申请人地址： CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： CA Oakland
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K9/127 ; A61K31/70 ; A61K31/7125 ; A61K38/00 ; A61K47/48 ; A61K48/00 ; A61P11/00 ; A61P13/00 ; A61P19/00 ; A61P43/00 ; C07D401/14 ; C07F9/10 ; C07K7/66 ; C07K14/025 ; C08G83/00 ; C12N15/87
摘要：
This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of this system include DNA-masking components, cell recognition components, charge-neutralization and membrane-permeabilization components, and subcellular localization components. Specific compounds useful in this system are also provided.
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