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29 条记录 (耗时 0.032 秒)

    Method for adjuvanting lipopolysaccharide (LPS) of gram-negative bacteria
    8.
    发明授权
    Method for adjuvanting lipopolysaccharide (LPS) of gram-negative bacteria 有权
    用于佐剂革兰氏阴性菌的脂多糖（LPS）的方法

    公开(公告)号：US08506971B2

    公开(公告)日：2013-08-13

    申请号：US12780388

    申请日：2010-05-14

    申请人： Jean Haensler ,  Bruno Guy

    发明人： Jean Haensler ,  Bruno Guy

    IPC分类号： A61K45/00 ,  A61K39/385 ,  A61K39/02 ,  A61K39/095 ,  A01N25/26

    CPC分类号： A61K39/095 ,  A61K9/1272 ,  A61K9/1277 ,  A61K39/02 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/6068

    摘要： The subject of the invention is a method for adjuvanting LPS of a Gram-negative bacterium, according to which LPS or LPS liposomes (LPS formulated in liposomes) is (are) mixed with the lipidated human-transferrin receptor subunit B (TbpB protein) of Neisseria meningitidis or a lipidated fragment thereof; or (ii) LPS and the lipidated TbpB of N. meningitidis or a lipidated fragment thereof are formulated together in liposomes; or (iii) LPS is conjugated with the lipidated TbpB of N. meningitidis or a lipidated fragment thereof; in order to obtain a preparation which does not contain OMVs and which is capable of inducing, after administration to a mammal, an anti-LPS immune response which is improved by comparison with the anti-LPS immune response observed after administration of the corresponding preparation in which the lipidated TbpB of N. meningitidis or a lipidated fragment thereof is omitted; as well as vaccine compositions thereof. The LPS may, for example, be the LOS of a non-enteric Gram-negative bacterium such as N. meningitidis.

    摘要翻译： 本发明的主题是用于对革兰氏阴性细菌的LPS进行佐剂化的方法，根据该方法将LPS或LPS脂质体（脂质体中配制的LPS）与脂质化的人 - 转铁蛋白受体亚基B（TbpB蛋白）混合 脑膜炎奈瑟氏球菌或其脂化片段; 或（ii）LPS和脑膜炎奈瑟氏球菌的脂化TbpB或其脂化片段一起配制在脂质体中; 或（iii）LPS与脑膜炎奈瑟氏球菌的脂化TbpB或其脂化片段缀合; 为了获得不含OMV的制剂，并且能够在给予哺乳动物之后诱导抗LPS免疫应答，所述抗LPS免疫应答与通过将相应制剂给药后观察到的抗LPS免疫应答相比得到改善 脑膜炎奈瑟氏球菌的脂质化TbpB或其脂化片段被省略; 以及其疫苗组合物。 LPS可以是例如非肠溶革兰氏阴性细菌如脑膜炎奈瑟氏球菌的LOS。

    Method for adjuvanting lipopolysaccharide (LPS) of Gram-negative bacteria
    9.
    发明申请
    Method for adjuvanting lipopolysaccharide (LPS) of Gram-negative bacteria 有权
    革兰阴性菌的脂多糖（LPS）佐剂的方法

    公开(公告)号：US20110014272A1

    公开(公告)日：2011-01-20

    申请号：US12780388

    申请日：2010-05-14

    申请人： Jean Haensler ,  Bruno Guy

    发明人： Jean Haensler ,  Bruno Guy

    IPC分类号： A61K9/127 ,  C07K17/02 ,  A61K39/385 ,  A61K39/095 ,  A61P31/04

    CPC分类号： A61K39/095 ,  A61K9/1272 ,  A61K9/1277 ,  A61K39/02 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/6068

    摘要： The subject of the invention is a method for adjuvanting LPS of a Gram-negative bacterium, according to which LPS or LPS liposomes (LPS formulated in liposomes) is (are) mixed with the lipidated human-transferrin receptor subunit B (TbpB protein) of Neisseria meningitidis or a lipidated fragment thereof; or (ii) LPS and the lipidated TbpB of N. meningitidis or a lipidated fragment thereof are formulated together in liposomes; or (iii) LPS is conjugated with the lipidated TbpB of N. meningitidis or a lipidated fragment thereof; in order to obtain a preparation which does not contain OMVs and which is capable of inducing, after administration to a mammal, an anti-LPS immune response which is improved by comparison with the anti-LPS immune response observed after administration of the corresponding preparation in which the lipidated TbpB of N. meningitidis or a lipidated fragment thereof is omitted; as well as vaccine compositions thereof. The LPS may, for example, be the LOS of a non-enteric Gram-negative bacterium such as N. meningitidis.

    摘要翻译： 本发明的主题是用于对革兰氏阴性细菌的LPS进行佐剂化的方法，根据该方法将LPS或LPS脂质体（脂质体中配制的LPS）与脂质化的人 - 转铁蛋白受体亚基B（TbpB蛋白）混合 脑膜炎奈瑟氏球菌或其脂化片段; 或（ii）LPS和脑膜炎奈瑟氏球菌的脂化TbpB或其脂化片段一起配制在脂质体中; 或（iii）LPS与脑膜炎奈瑟氏球菌的脂化TbpB或其脂化片段缀合; 为了获得不含OMV的制剂，并且能够在给予哺乳动物之后诱导抗LPS免疫应答，所述抗LPS免疫应答与通过将相应制剂给药后观察到的抗LPS免疫应答相比得到改善 脑膜炎奈瑟氏球菌的脂质化TbpB或其脂化片段被省略; 以及其疫苗组合物。 LPS可以是例如非肠溶革兰氏阴性细菌如脑膜炎奈瑟氏球菌的LOS。

    Pharmaceutical composition for immunization against AIDS
    10.
    发明申请
    Pharmaceutical composition for immunization against AIDS 审中-公开
    用于免疫艾滋病的药物组合物

    公开(公告)号：US20050118188A1

    公开(公告)日：2005-06-02

    申请号：US10957010

    申请日：2004-10-01

    申请人： Francois Dalenccon ,  Jean Haensler

    发明人： Francois Dalenccon ,  Jean Haensler

    IPC分类号： A61K39/21 ,  A61K39/39 ,  A61P31/00 ,  A61K39/02

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/57 ,  C12N2740/16134

    摘要： The invention relates to the field of pharmaceutical compositions for use in immunization against HIV-related infections, and concerns a pharmaceutical composition comprising at least an HIV antigen and DCchol. Such a composition has proved to be particularly interesting for inducing through the mucus system IgG and IgA specific to the administered antigen. The inventive pharmaceutical composition, in a particularly advantageous manner, can be in the form of a liposome suspension or emulsion.

    摘要翻译： 本发明涉及用于免疫HIV相关感染的药物组合物领域，涉及包含至少一种HIV抗原和DCchol的药物组合物。 已经证明，通过对施用的抗原特异性的粘液系统IgG和IgA诱导这种组合是特别有趣的。 本发明的药物组合物以特别有利的方式可以是脂质体悬浮液或乳液的形式。