- 专利标题： Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
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申请号： US512815申请日： 1995-08-09
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公开(公告)号： US5978740A公开(公告)日： 1999-11-02
- 发明人: David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
- 申请人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
- 申请人地址： MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： MA Cambridge
- 主分类号： C12N9/16
- IPC分类号： C12N9/16 ; G06F17/50 ; G06F19/00
摘要：
The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
公开/授权文献
- US4519864A Method of making a paper pattern for dyeing 公开/授权日：1985-05-28
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