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公开(公告)号：US5978740A
公开(公告)日：1999-11-02
申请号：US512815
申请日：1995-08-09
申请人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
发明人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
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2.发明授权Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 失效包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质公开(公告)号：US07065452B1
公开(公告)日：2006-06-20
申请号：US09431469
申请日：1999-11-01
申请人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
发明人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
摘要翻译： 本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。 本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。 这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。 此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。 本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。
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3.发明授权
公开(公告)号：US6057119A
公开(公告)日：2000-05-02
申请号：US450362
申请日：1995-05-25
CPC分类号： C12N9/6475 , C12Q1/37 , C07K2299/00 , G01N2333/96466
摘要： Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.
摘要翻译： 白细胞介素-1β转换酶（“ICE”）处理促炎细胞因子白细胞介素-1β的无活性前体。 通过X射线衍射测定人体ICE与抑制剂复合物结晶的高分辨率结构。 活性位点跨越10和20千道尔顿亚单位。 辅助结合位点由与晶体双折轴相邻的p10和p20亚基的残基组成。 酶的结构坐标可用于设计新型的ICE抑制剂。
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公开(公告)号：US5856116A
公开(公告)日：1999-01-05
申请号：US450130
申请日：1995-05-25
CPC分类号： C12N9/6475 , C12Q1/37 , C07K2299/00 , G01N2333/96466
摘要： Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.
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