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    Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket
    3.
    发明授权
    Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket 失效
    使用包含IMPDH样结合口袋的分子的结构坐标的方法

    公开(公告)号：US07216041B1

    公开(公告)日：2007-05-08

    申请号：US09678016

    申请日：2000-10-02

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
    4.
    发明授权
    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
    包含IMPDH样结合袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US06128582A

    公开(公告)日：2000-10-03

    申请号：US640164

    申请日：1996-04-30

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： A61K31/00 ,  A61K31/365 ,  A61K45/00 ,  A61P43/00 ,  C07K1/00 ,  C07K1/14 ,  C12N9/04 ,  C12Q1/32 ,  G06F17/30 ,  G06F17/50 ,  G06F19/00

    CPC分类号： C12Q1/32 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706 ,  C07K2299/00

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)
    5.
    发明授权
    Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA) 失效
    肌苷单磷酸脱氢酶/氧化肌苷单磷酸硫酸酯中间体/霉酚酸（IIMPDH / XMP * / MPA）

    公开(公告)号：US07527952B2

    公开(公告)日：2009-05-05

    申请号：US11645289

    申请日：2006-12-21

    申请人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    发明人： Keith P. Wilson ,  Michael D. Sintchak ,  Mark Andrew Fleming ,  David M. Armistead

    IPC分类号： C12P21/06 ,  C12N9/04

    CPC分类号： C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    摘要翻译： 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Crystal structure and mutants of interleukin-1.beta. converting enzyme
    6.
    发明授权
    Crystal structure and mutants of interleukin-1.beta. converting enzyme 失效
    白介素-1β转化酶的晶体结构和突变体

    公开(公告)号：US6057119A

    公开(公告)日：2000-05-02

    申请号：US450362

    申请日：1995-05-25

    申请人： Keith P. Wilson ,  James P. Griffith ,  Eunice E. Kim ,  David J. Livingston

    发明人： Keith P. Wilson ,  James P. Griffith ,  Eunice E. Kim ,  David J. Livingston

    IPC分类号： G01N33/68 ,  C12N9/64 ,  C12N15/09 ,  C12Q1/37

    CPC分类号： C12N9/6475 ,  C12Q1/37 ,  C07K2299/00 ,  G01N2333/96466

    摘要： Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.

    摘要翻译： 白细胞介素-1β转换酶（“ICE”）处理促炎细胞因子白细胞介素-1β的无活性前体。 通过X射线衍射测定人体ICE与抑制剂复合物结晶的高分辨率结构。 活性位点跨越10和20千道尔顿亚单位。 辅助结合位点由与晶体双折轴相邻的p10和p20亚基的残基组成。 酶的结构坐标可用于设计新型的ICE抑制剂。

    Crystallizable JNK complexes
    9.
    发明申请
    Crystallizable JNK complexes 失效
    可结晶JNK复合物

    公开(公告)号：US20090186394A1

    公开(公告)日：2009-07-23

    申请号：US12150328

    申请日：2008-04-25

    申请人： Xiaoling Xie ,  Yong Gu ,  William Markland ,  Michael S. Su ,  Paul R. Caron ,  Edward Fox ,  Keith P. Wilson

    发明人： Xiaoling Xie ,  Yong Gu ,  William Markland ,  Michael S. Su ,  Paul R. Caron ,  Edward Fox ,  Keith P. Wilson

    IPC分类号： C12N9/12 ,  G06F17/50

    CPC分类号： C12Q1/485 ,  C07K2299/00 ,  G01N2333/9121 ,  G01N2500/00 ,  G06F19/16

    摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

    摘要翻译： 本发明涉及用包含JNK3的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 包括这种数据存储材料的计算机能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计与JNK3或其同系物结合的化合物（包括抑制性化合物）的方法。 本发明还涉及分子和分子复合物，其包含JNK3的活性位点结合口袋或活性位点结合口袋的紧密结构同源物。