发明授权
- 专利标题： Production of biologically active NGF proteins
- 专利标题（中）： 生物活性NGF蛋白的生产
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申请号： US918101申请日： 1997-08-27
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公开(公告)号： US5986070A公开(公告)日： 1999-11-16
- 发明人: Frank D. Collins , Jack Lile , Susan Becktesh , Tadahiko Kohno , Drizislav Mismer, deceased
- 申请人： Frank D. Collins , Jack Lile , Susan Becktesh , Tadahiko Kohno , Drizislav Mismer, deceased
- 申请人地址： CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： CA Thousand Oaks
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/475 ; C07K14/48 ; C07K14/50 ; C12N15/70 ; C07K1/14
摘要：
This invention describes processes for producing mature human members of the NGF/BDNF family of neurotrophic proteins that are fully biologically active. In addition, the gene encoding human BDNF and human BDNF are disclosed. A previously-unreported member of the NGF/BDNF family of neurotrophic proteins, NGF-3, has been identified and a portion of the gene encoding for the NGF-3 has been described.
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