发明授权
US5994524A Polynucleotides which encode reshaped IL-8-specific antibodies and
methods to produce the same
失效
编码重组的IL-8特异性抗体的多核苷酸及其制备方法
- 专利标题： Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same
- 专利标题（中）： 编码重组的IL-8特异性抗体的多核苷酸及其制备方法
-
申请号： US765783申请日： 1997-03-07
-
公开(公告)号： US5994524A公开(公告)日： 1999-11-30
- 发明人: Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
- 申请人： Kouji Matsushima , Yoshihiro Matsumoto , Yoshiki Yamada , Koh Sato , Masayuki Tsuchiya , Tatsumi Yamazaki
- 申请人地址： JPX Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX6-161481 19940713; JPX6-289951 19941124; JPX6-310785 19941214
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; C12N15/13 ; C12P21/08 ; C07H21/04 ; C12N5/10
摘要：
The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.