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    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same
    2.
    发明授权
    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same 失效
    编码重组的IL-8特异性抗体的多核苷酸及其制备方法

    公开(公告)号：US5994524A

    公开(公告)日：1999-11-30

    申请号：US765783

    申请日：1997-03-07

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K16/24 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  C12N5/10

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.

    摘要翻译： PCT No.PCT / JP95 / 01396 Sec。 371日期1997年3月7日 102（e）1997年3月7日PCT PCT 1995年7月12日PCT公布。 出版物WO97 / 02576 日本1996年2月1日本发明公开了针对人IL-8的重构人抗体，其包含：（A）L链，各自包含：（1）人L链C区; 和（2）包含人L链FR的L链V区和针对人IL-8的小鼠单克隆抗体的L链CDR; 和（B）H链，其各自包含：（1）人H链C区; 和（2）包含人H链FR的H链V区和针对人IL-8的小鼠单克隆抗体的H链CDR。 由于这种重整人抗体的大部分源于人抗体，CDR具有低抗原性，所以本发明的重构人抗体对人的抗原性低，因此可以预期可用于治疗。 本发明进一步公开了编码针对IL-8的重整抗体以及宿主细胞的多核苷酸以及产生这些抗体的方法。

    Reshaped human antibody to human interleukin-8
    3.
    发明授权
    Reshaped human antibody to human interleukin-8 有权
    重组人抗人白介素-8抗体

    公开(公告)号：US06245894B1

    公开(公告)日：2001-06-12

    申请号：US09416557

    申请日：1999-10-12

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K1400

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： A reshaped human antibody is characterized as having the same binding affinity for IL-8 as a chimeric antibody but with low immunogenicity in comparison. The reshaped antibody has the following elements: a human L chain C region or a human L chain FR and an L chain CDR from a mouse monoclonal antibody against human IL-8 and a human H chain C region or a human H chain FR and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the reshaped human antibody has low immunogenicity to humans, it is suitable for use in medical treatment of a variety of medical conditions.

    摘要翻译： 重整的人抗体的特征在于具有与嵌合抗体相同的IL-8的结合亲和力，但相比之下具有低的免疫原性。 重构抗体具有以下元件：来自针对人IL-8和人H链C区或人H链FR的小鼠单克隆抗体的人L链C区或人L链FR和L链CDR， 小鼠单克隆抗体针对人IL-8的H链CDR。 由于重整人抗体对人的免疫原性低，因此适用于各种医疗条件的医疗。

    Isolated converter
    7.
    发明授权
    Isolated converter 有权

    公开(公告)号：US06373736B1

    公开(公告)日：2002-04-16

    申请号：US09880606

    申请日：2001-06-13

    申请人： Yoshihiro Matsumoto ,  Tadahiko Matsumoto

    发明人： Yoshihiro Matsumoto ,  Tadahiko Matsumoto

    IPC分类号： H02M100

    摘要： An isolated converter with a reduced size is disclosed. A small-sized multilayer sheet transformer includes a multilayer circuit board composed of a plurality of sheet substrates, coil patterns of primary and secondary coils disposed coaxially on the sheet substrates, and a core member disposed in a coil pattern unit formed of the coil patterns. In this multilayer sheet transformer, a coil pattern formed on the outer surface of the top layer and a coil pattern formed on the outer surface of the bottom layer are for the same coil on either the primary or secondary side. In the case where the coil patterns formed on the outer surfaces of the top and bottom layers of the multilayer sheet transformer are for the primary coil, an isolation gap is formed between the multilayer sheet transformer and a circuit on the secondary side to prevent an electrical breakdown between the primary and secondary sides. In the case where the coil patterns formed on the outer surfaces of the top and bottom layers of the multilayer sheet transformer are for the secondary coil, an isolation gap is formed between the multilayer sheet transformer and a circuit on the primary side to prevent an electrical breakdown between the primary and secondary sides.

    Binocular telescope
    8.
    发明授权
    Binocular telescope 失效
    双目望远镜

    公开(公告)号：US5949575A

    公开(公告)日：1999-09-07

    申请号：US517260

    申请日：1995-08-22

    申请人： Yoshihiro Matsumoto

    发明人： Yoshihiro Matsumoto

    IPC分类号： G02B7/12 ,  G02B23/18 ,  G02B7/06 ,  G02B7/11

    CPC分类号： G02B7/12 ,  G02B23/18

    摘要： A binocular telescope provided with a pair of left and right lens-barrels respectively containing optical systems, a first guide shaft for supporting these lens-barrels in such a manner that the lens-barrels can slide in a direction perpendicular to the optical axes of the optical systems and can rotate, a second guide shaft for restraining the relative tilt of the lens-barrels around this first guide shaft in such a manner that the optical axes of the left and right optical systems become parallel to each other, a first rib for holding both ends of the first guide shaft by fitting upper and lower covers to each other, and a second rib for restraining the tilt of the optical axes of the entire lens-barrels around the first guide shaft.

    摘要翻译： 一双眼望远镜，设有一对分别容纳光学系统的左右透镜筒，一个用于支撑这些透镜筒的第一引导轴，使得透镜筒能够沿垂直于光学系统的光轴的方向滑动 光学系统并且可以旋转;第二引导轴，用于以使得左右光学系统的光轴彼此平行的方式限制透镜套围绕该第一引导轴的相对倾斜;第一肋，用于 通过将上盖和下盖彼此嵌合来保持第一引导轴的两端;以及第二肋，用于限制整个透镜套的光轴围绕第一引导轴的倾斜。

    Optical system having compound prism design to reduce ghosts and plares
    9.
    发明授权
    Optical system having compound prism design to reduce ghosts and plares 失效
    具有复合棱镜设计的光学系统，以减少重影和复制

    公开(公告)号：US5835276A

    公开(公告)日：1998-11-10

    申请号：US801995

    申请日：1997-02-18

    申请人： Tetsuhisa Asai ,  Masashi Hankawa ,  Yoshihiro Matsumoto

    发明人： Tetsuhisa Asai ,  Masashi Hankawa ,  Yoshihiro Matsumoto

    IPC分类号： G02B23/14 ,  G02B5/00 ,  G02B5/04 ,  G02B17/00 ,  G02B27/00 ,  G02B27/14 ,  G02B27/12

    CPC分类号： G02B27/0018

    摘要： A prism optical system provided with: a first prism on which a light ray coming from an objective lens is incident; a second prism on which the light ray coming from this first prism is incident, and from which this incident light ray is emitted; and a plate-like member which is interposed between the aforesaid prisms so as to provide a predetermined air space therebetween and which has a diaphragm opening and a light blocking portion. Further, an uneven portion, which consists of depressions and projections and has a serrate section, for preventing light rays, which have been reflected from the surface of the light blocking portion of this plate-like member, from entering a field stop is provided in the light blocking portion thereof. Thereby, occurrences of ghosts and flares due to stray light are prevented. Moreover, ghosts and flares are reduced.

    摘要翻译： 一种棱镜光学系统，其具有：来自物镜的光线入射的第一棱镜; 来自该第一棱镜的光线入射到其上的第二棱镜，并从该第二棱镜射出该入射光线; 以及设置在上述棱镜之间以在其间提供预定空气空间并且具有光阑开口和遮光部分的板状构件。 此外，在该板状构件的遮光部的表面反射的防止光线的凹凸部具有锯齿状的凹凸部不平整部分设置在 其遮光部分。 因此，防止由于杂散光而发生的鬼影和耀斑。 此外，鬼魂和耀斑也减少了。

    Interpupillary distance adjusting mechanism for use in binocular telescope
    10.
    发明授权
    Interpupillary distance adjusting mechanism for use in binocular telescope 失效
    用于双目望远镜的瞳距调整机构

    公开(公告)号：US5734499A

    公开(公告)日：1998-03-31

    申请号：US510918

    申请日：1995-08-03

    申请人： Yoshihiro Matsumoto ,  Fumio Tomikawa

    发明人： Yoshihiro Matsumoto ,  Fumio Tomikawa

    IPC分类号： G02B23/18 ,  G02B7/12 ,  G02B23/00

    CPC分类号： G02B7/12

    摘要： An interpupillary distance adjusting mechanism for use in a binocular telescope, having a pair of lens-barrels which contain lens optical systems, respectively, and are placed in parallel with each other. The interpupillary distance adjusting mechanism further has first and second guide shafts, which slidably guide the pair of lens-barrels in a direction substantially perpendicular to the direction of the optical axes of the lens optical systems, interpupillary distance adjusting springs for pushing the pair of lens-barrels in a sliding direction, and an interpupillary distance adjusting cam which can adjust an interpupillary distance by sliding the pair of lens-barrels along the guide shafts as the result of undergoing a pushing force from the interpupillary distance adjusting spring, of converting a part of the pushing force in a direction which intersects the sliding direction, and of moving the pair of lens-barrels by pushing the pair of lens-barrels against the first guide.

    摘要翻译： 一种用于双目望远镜的瞳孔间距调节机构，具有分别包含透镜光学系统并且彼此平行放置的一对透镜筒。 瞳孔间距调节机构还具有第一和第二引导轴，其在基本上垂直于透镜光学系统的光轴的方向的方向上可滑动地引导一对透镜筒，用于推动该对透镜的瞳孔间距调节弹簧 以及瞳孔间距调节凸轮，其可以通过从所述瞳孔间距调节弹簧经受推力而沿着所述引导轴滑动所述一对透镜镜筒来调节瞳孔间距离，从而将部件 的推力与滑动方向相交的方向，以及通过将一对透镜筒推靠在第一引导件上来移动一对透镜筒。