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29 条记录 (耗时 0.029 秒)

    Reshaped human antibody to human interleukin-8
    2.
    发明授权
    Reshaped human antibody to human interleukin-8 有权
    重组人抗人白介素-8抗体

    公开(公告)号：US06245894B1

    公开(公告)日：2001-06-12

    申请号：US09416557

    申请日：1999-10-12

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K1400

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： A reshaped human antibody is characterized as having the same binding affinity for IL-8 as a chimeric antibody but with low immunogenicity in comparison. The reshaped antibody has the following elements: a human L chain C region or a human L chain FR and an L chain CDR from a mouse monoclonal antibody against human IL-8 and a human H chain C region or a human H chain FR and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the reshaped human antibody has low immunogenicity to humans, it is suitable for use in medical treatment of a variety of medical conditions.

    摘要翻译： 重整的人抗体的特征在于具有与嵌合抗体相同的IL-8的结合亲和力，但相比之下具有低的免疫原性。 重构抗体具有以下元件：来自针对人IL-8和人H链C区或人H链FR的小鼠单克隆抗体的人L链C区或人L链FR和L链CDR， 小鼠单克隆抗体针对人IL-8的H链CDR。 由于重整人抗体对人的免疫原性低，因此适用于各种医疗条件的医疗。

    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same
    5.
    发明授权
    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same 失效
    编码重组的IL-8特异性抗体的多核苷酸及其制备方法

    公开(公告)号：US5994524A

    公开(公告)日：1999-11-30

    申请号：US765783

    申请日：1997-03-07

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K16/24 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  C12N5/10

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.

    摘要翻译： PCT No.PCT / JP95 / 01396 Sec。 371日期1997年3月7日 102（e）1997年3月7日PCT PCT 1995年7月12日PCT公布。 出版物WO97 / 02576 日本1996年2月1日本发明公开了针对人IL-8的重构人抗体，其包含：（A）L链，各自包含：（1）人L链C区; 和（2）包含人L链FR的L链V区和针对人IL-8的小鼠单克隆抗体的L链CDR; 和（B）H链，其各自包含：（1）人H链C区; 和（2）包含人H链FR的H链V区和针对人IL-8的小鼠单克隆抗体的H链CDR。 由于这种重整人抗体的大部分源于人抗体，CDR具有低抗原性，所以本发明的重构人抗体对人的抗原性低，因此可以预期可用于治疗。 本发明进一步公开了编码针对IL-8的重整抗体以及宿主细胞的多核苷酸以及产生这些抗体的方法。

    Transgenic mice expressing baculovirus soluble GP64 and methods of using such mice to make antibodies
    7.
    发明授权
    Transgenic mice expressing baculovirus soluble GP64 and methods of using such mice to make antibodies 有权
    表达杆状病毒可溶性GP64的转基因小鼠和使用这种小鼠制备抗体的方法

    公开(公告)号：US07964767B2

    公开(公告)日：2011-06-21

    申请号：US10594690

    申请日：2005-03-31

    申请人： Tatsuhiko Kodama ,  Yoshiki Yamada ,  Nobuo Kamada ,  Kou-Ichi Jishage

    发明人： Tatsuhiko Kodama ,  Yoshiki Yamada ,  Nobuo Kamada ,  Kou-Ichi Jishage

    IPC分类号： A01K67/027 ,  C12P21/00

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2267/01 ,  A01K2267/02 ,  A01K2267/03 ,  C07K14/005 ,  C07K16/00 ,  C12N2710/14022

    摘要： Membrane proteins that are background antigens were solubilized, and transgenic animals were produced using genes encoding these soluble proteins. Antibodies against the background antigen membrane proteins comprised in the immunogens were not found in these transgenic animals, and even when genes encoding soluble proteins were used, immunotolerance against the full-length membrane proteins could be induced. Moreover, by expressing the background antigen membrane proteins as soluble proteins inside the bodies of transgenic animals, unfavorable phenotypes that appear when the full-length membrane proteins are expressed could be avoided, and such animals were made widely available as immunized animals.

    摘要翻译： 溶解背景抗原的膜蛋白，使用编码这些可溶蛋白的基因产生转基因动物。 在这些转基因动物中没有发现针对免疫原中包含的背景抗原膜蛋白的抗体，即使使用编码可溶性蛋白质的基因，也可以诱导针对全长膜蛋白的免疫耐受性。 此外，通过将背景抗原膜蛋白质表达为转基因动物体内的可溶性蛋白质，可以避免在全长膜蛋白质表达时出现的不利表型，并且这样的动物作为免疫动物被广泛使用。

    Sensor chip and storage method thereof
    10.
    发明授权
    Sensor chip and storage method thereof 有权
    传感器芯片及其存储方法

    公开(公告)号：US08702930B2

    公开(公告)日：2014-04-22

    申请号：US13636976

    申请日：2012-01-11

    申请人： Kiyoshi Hashimotodani ,  Yusuke Nakano ,  Masaya Nakatani ,  Takeki Yamamoto ,  Yoshiki Yamada ,  Takuya Oka ,  Hiroshi Ushio

    发明人： Kiyoshi Hashimotodani ,  Yusuke Nakano ,  Masaya Nakatani ,  Takeki Yamamoto ,  Yoshiki Yamada ,  Takuya Oka ,  Hiroshi Ushio

    IPC分类号： G01N33/487 ,  G01N27/28

    CPC分类号： G01N33/48728 ,  Y10T428/31663

    摘要： A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.

    摘要翻译： 传感器芯片是用于通过将物质吸附在传感器芯片的表面上来测量物质的性质的传感器装置。 传感器芯片包括具有第一表面，第二表面和从第一表面穿透到第二表面的至少一个通孔的隔膜。 第一表面，第二表面和通孔的内壁表面的至少一部分被包括SiO x作为主要成分的非结晶固体层覆盖，其中物质X是比硅的电负性高的元素 。