发明授权
- 专利标题: Transdermal protein delivery using low-frequency sonophoresis
- 专利标题(中): 透皮蛋白递送使用低频超声波
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申请号: US507060申请日: 1995-07-25
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公开(公告)号: US6002961A公开(公告)日: 1999-12-14
- 发明人: Samir S. Mitragotri , Daniel Blankschtein , Robert S. Langer
- 申请人: Samir S. Mitragotri , Daniel Blankschtein , Robert S. Langer
- 申请人地址: MA Cambridge
- 专利权人: Massachusetts Institute of Technology
- 当前专利权人: Massachusetts Institute of Technology
- 当前专利权人地址: MA Cambridge
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K41/00 ; A61M37/00 ; A61N1/32 ; A61B17/00
摘要:
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
公开/授权文献
- USD337724S Bottle 公开/授权日:1993-07-27
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