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US6002961A Transdermal protein delivery using low-frequency sonophoresis 失效
透皮蛋白递送使用低频超声波

Transdermal protein delivery using low-frequency sonophoresis
摘要:
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
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